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Dietary patterns and risk of squamous-cell carcinoma and adenocarcinoma of the esophagus and adenocarcinoma of the gastric cardia: A population-based case-control study in Sweden

Bahmanyar, S. and Ye, W. (2006) Dietary patterns and risk of squamous-cell carcinoma and adenocarcinoma of the esophagus and adenocarcinoma of the gastric cardia: A population-based case-control study in Sweden. Nutrition and Cancer, 54 (2). pp. 171-178. ISSN 01635581 (ISSN)

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Abstract

We conducted a large population-based case-control study in Sweden to examine the association of dietary patterns and the development of cancers from the esophagus or gastroesophageal junction. In total 185 patients with esophageal adenocarcinoma, 165 with esophageal squamous-cell carcinoma, 258 with gastric cardia adenocarcinoma, and 815 randomly selected population controls underwent face-to-face interviews. Exploratory factor analysis was used to identify possible dietary patterns. Multivariate logistic regression with adjustments for age, sex, years of education, body mass index, physical activity, symptomatic gastroesophageal reflux, smoking, and total energy intake was used to estimate odds ratios (ORs) and their 95% confidence intervals (CIs). We identified three major dietary patterns in this population, for example, "healthy diet" (high in vegetables, tomato, fruits, fish, and poultry), "Western diet" (high in processed meat, red meat, sweets, high-fat dairy, and high-fat gravy), and "alcohol drinker" (high in intakes of beer, liquor, and French fries). We found that a healthy diet tended to moderately decrease the risk of all three cancers under study, although none of the associations was statistically significant. A high score of Western diet was associated with increased risks of gastric cardia adenocarcinoma (high 3rd fertile vs. low 1st quartile, OR = 1.8, 95% CI = 1.1-2.9, P for trend = 0.04) and esophageal adenocarcinoma (high 3rd fertile vs. low 1st fertile, OR = 1.6, 95% CI = 0.9-3.1, P for trend = 0.13), whereas a dietary pattern characterized by high beer and liquor intake (alcohol drinker) significantly increased the risk of squamous-cell carcinoma of the esophagus (3rd fertile vs. low 1st fertile, OR = 3.5, 95% CI = 1.9-6.3, P for trend < 0.0001). Our study confirms the important role of diet in the carcinogenesis of esophageal and cardia cancer. Copyright © 2006, Lawrence Erlbaum Associates, Inc.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Nutr. Cancer [Field not mapped to EPrints] C2 - 16898861 [Field not mapped to EPrints] AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-171 77, Stockholm, Sweden [Field not mapped to EPrints] AD - Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm, Sweden [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: academic achievement, adenocarcinoma, age, aged, alcohol consumption, alcoholic beverage, article, beer, body mass, caloric intake, cancer risk, cardia carcinoma, dairy product, diet, disease association, education, esophageal adenocarcinoma, esophagus carcinoma, factorial analysis, female, fish, food intake, food processing, fruit, gastroesophageal reflux, gender, health behavior, human, lipid diet, major clinical study, male, meat, multivariate logistic regression analysis, physical activity, potato, poultry, scoring system, smoking, squamous cell carcinoma, statistical significance, sugar intake, symptom, tomato, vegetable, Adenocarcinoma, Aged, Alcohol Drinking, Carcinoma, Squamous Cell, Cardia, Case-Control Studies, Diet Surveys, Esophageal Neoplasms, Factor Analysis, Statistical, Female, Food Habits, Humans, Male, Meat, Odds Ratio, Risk Assessment, Risk Factors, Stomach Neoplasms, Sweden, Lycopersicon esculentum
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 07:01
Last Modified: 07 Feb 2017 07:29
URI: http://eprints.goums.ac.ir/id/eprint/2433

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