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Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males

Tavilani, H. and Doosti, M. and Abdi, K. and Vaisiraygani, A. and Joshaghani, H.R. (2006) Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males. Andrologia, 38 (5). pp. 173-178. ISSN 03034569 (ISSN)

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Abstract

The lipid composition of the sperm membrane has been shown to exert a significant effect upon the functional quality of spermatozoa. We have studied fatty acid composition of the phospholipids in spermatozoa in asthenozoospermic and normozoospermic men and determined the ratio of polyunsaturated fatty acids (PUFAs) to saturated fatty acids of spermatozoa of these two groups. Fatty acid concentration of spermatozoa was determined in 15 asthenozoospermic and eight normozoospermic semen samples by thin layer chromatography and gas chromatography. The most abundant polyunsaturated and saturated fatty acids in normozoospermic samples were docosahexaenoic acid (DHA 22: 6 ω3, 98.5 ± 4.5 nmol per 108 spermatozoa, mean ± SE) and palmitic acid (103 ± 17 nmol per 108 spermatozoa) respectively. The mean ± SE values of DHA and palmitic acid in asthenozoospermic samples were 53.9 ± 11.6 and 145 ± 14.7 nmol per 108 spermatozoa respectively. Compared with normozoospermic samples, asthenozoospermic samples showed lower levels of PUFA and higher amount of saturated fatty acids. The mean ± SE ratios of sperm PUFA/saturated fatty acids in asthenozoospermic and normozoospermic samples were 0.66 ± 0.06 and 1.45 ± 0.16 (P < 0.001) respectively. This study demonstrates that spermatozoa of asthenozoospermic men have lower levels of PUFA compared with saturated fatty acids. This may be contributory to the poor motility noted in samples from these men. © 2006 The Authors.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Andrologia [Field not mapped to EPrints] C2 - 16961570 [Field not mapped to EPrints] AD - Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Science, Hamadan, Iran [Field not mapped to EPrints] AD - Department of Medical Biochemistry, Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran [Field not mapped to EPrints] AD - Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran [Field not mapped to EPrints] AD - Department of Clinical Biochemistry, Faculty of Medicine, Kermanshah University of Medical Science, Kermanshah, Iran [Field not mapped to EPrints] AD - Department of Medical Laboratory Technology, School of Paramedicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Asthenozoospermia, Polyunsaturated fatty acid, Saturated fatty acid, Spermatozoa, docosahexaenoic acid, myristic acid, palmitic acid, phospholipid derivative, polyunsaturated fatty acid, saturated fatty acid, adult, article, asthenospermia, chromatography, clinical article, controlled study, gas chromatography, human, lipid composition, male, sperm, spermatozoon, Adult, alpha-Linolenic Acid, Arachidonic Acid, Docosahexaenoic Acids, Fatty Acids, Fatty Acids, Unsaturated, Humans, Infertility, Male, Linoleic Acid, Male, Myristic Acid, Palmitic Acid, Spermatozoa, Stearic Acids
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 08:54
Last Modified: 07 Feb 2017 06:38
URI: http://eprints.goums.ac.ir/id/eprint/2431

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