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Serum cholinesterase level reduction in pesticide factory workers

Joshaghani, H.R. and Mansourian, A.R. and Ahmadi, A.R. and Tavilani, H. (2006) Serum cholinesterase level reduction in pesticide factory workers. Journal of Medical Sciences, 6 (6). pp. 1025-1028. ISSN 16824474 (ISSN)

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Abstract

In this study the sampling from 63 subjects was carried out for two sessions in days 1 and 90. Cholinesterase determination was performed with butyrylthiocholine substrate and enzymatic test was done using kinetic techniques. The mean serum cholinesterase level in phase 1 was 9569±2496 IU L-1 and in second phase the activity of cholinesterase was 7970±2067 IU L-1. This drop in cholinesterase level statistically was meaningful (paired t-test, mean = 1599, 95% CI = 1140-2058, p<0.001). ALT increase in second phase compared to first phase statistically was meaningful (Paired t-test, mean = -7.9, 95% CI = -10.9 -4.9, p<0.001). In this study eight subjects (12.7%) bad more than 35% reduction in cholinesterase activity. In regard to reduction in cholinesterase activity of 17 workers which include 27% of working personals in a three months period it seems logical to set a program to have a routine check on the cholinesterase activity in working personal engaging in such occupations.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Med. Sci. (Pakistan) [Field not mapped to EPrints] AD - Department of Medical Laboratory Technology, School of Paramedicine, Golestan University of Medical Sciences, Hircan Boulevard, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Biochemistry, Faculty of Medicine, Golestan University of Medical Sciences, Hircan Boulevard, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Biochemistry, Faculty of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Cholinesterase, Iran, Organophosphate, Pesticide, Serum, alanine aminotransferase, butyrylthiocholine, cholinesterase, pesticide, adult, alanine aminotransferase blood level, article, cholinesterase blood level, enzyme activity, enzyme assay, human, industrial worker, liver disease, liver toxicity, major clinical study, occupational disease, occupational exposure, occupational hazard, occupational health, Student t test
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 04:32
Last Modified: 07 Feb 2017 10:41
URI: http://eprints.goums.ac.ir/id/eprint/2428

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