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Effects of occupational exposure in pesticide plant on workers' serum and erythrocyte cholinesterase activity

Joshaghani, H.R. and Ahmadi, A.R. and Mansourian, A.R. (2007) Effects of occupational exposure in pesticide plant on workers' serum and erythrocyte cholinesterase activity. International Journal of Occupational Medicine and Environmental Health, 20 (4). pp. 381-385. ISSN 12321087 (ISSN)

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Abstract

Objectives: The determination of cholinesterase activity has been commonly applied in the biomonitoring of exposure to organophosphates and carbamates and in the diagnosis of poisoning with anticholinesterase compounds. One of the groups who are at risk of pesticide intoxication are the workers engaged in the production of these chemicals. Aims: The aim of this study was to assess the effect of pesticides on erythrocyte and serum cholinesterase activity in workers occupationally exposed to these chemicals. Methods: The subjects were 63 workers at a pesticide plant. Blood samples were collected before they were employed (phase I) and after 3 months of working in the plant (phase II). Cholinesterase level in erythrocytes (EChE) was determined using the modified Ellman method, and serum cholinesterase (SChE) by butyrylthiocholine substrate assay. Results: The mean EChE levels were 48±11 IU/g Hb in phase I and 37±17 IU/g Hb in phase II (paired t-test, mean = -29; 95% CI = -43-14), p < 0.001). The mean SChE level was 9569±2496 IU/l in phase I, and 7970±2067 IU/l in phase II (paired t-test, mean = 1599; 95% CI = 1140-2058, p < 0.001). There was a significant increase in ALT level (p < 0.001) and a decrease in serum albumin level (p < 0.001). Conclusion: In view of the significant decrease in EChE and SChE levels among pesticide workers, it seems that routine assessment of cholinesterase level in workers employed in such occupations and people handling pesticides should be made obligatory.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Int. J. Occup. Med. Environ. Health [Field not mapped to EPrints] C2 - 18165198 [Field not mapped to EPrints] AD - Department of Medical Laboratory Technology, School of Paramedicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Biochemistry, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Medical Laboratory Technology, School of Paramedicine, Building of Falsfati, Hirean Boulevard, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Cholinesterase, Occupational, Organophosphate, Pesticide, acetylcholinesterase, butyrylthiocholine, organophosphate, pesticide, serum albumin, adult, article, blood sampling, cell level, controlled study, enzyme activity, enzyme assay, enzyme blood level, enzyme substrate, health status, high risk population, human, human experiment, intoxication, normal human, occupational exposure, occupational hazard, Student t test, worker, Adult, Carbamates, Chemical Industry, Cholinesterases, Cohort Studies, Erythrocytes, Humans, Middle Aged, Occupational Exposure, Pesticides, Phosphoric Acid Esters
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 05:23
Last Modified: 13 Feb 2017 05:57
URI: http://eprints.goums.ac.ir/id/eprint/2416

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