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The protective activity of Urtica dioica leaves on blood glucose concentration and β-cells in streptozotocin-diabetic rats

Golalipour, M.J. and Khori, V. (2007) The protective activity of Urtica dioica leaves on blood glucose concentration and β-cells in streptozotocin-diabetic rats. Pakistan Journal of Biological Sciences, 10 (8). pp. 1200-1204. ISSN 10288880 (ISSN)

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Abstract

This study was done to determine the protective activity of the hydroalcholic extract of Urtica dioica leaves on Hyperglycemia and P-cells in hyperglycemic rats. Thirty Wistar rats were allocated in groups of normal, Diabetic and treatment. Hyperglycemia in Rats induced by 80 mg kg-1 streptozotocin. In treatment group, animals received hydroalcholic extract of Urtica dioica 100 mg kg-1 day-1 for five days, intraperitoneally and then hyperglycemia induced by streptozotocin. The blood glucose concentration was measured by using a Glucometer in 1st, 3rd and 5th weeks. In the end of 5th weeks the animals in each group were sacrificed by anesthesia and whole pancreas in three groups extracted and fixed in bouin's fluid and stained by chromealum hematoxiline-phloxine and beta cells were counted in three groups by Olympus microscope. Mean±SE of blood glucose concentrations in the end of fifth weeks were 99.4±5.0,454.7±34.5 and 303.6±100.6 in control, diabetic and treatment groups, respectively (p<0.05). The percentages of β-cells in control, diabetic and treatment groups were 73.6, 1.9 and 22.9%, respectively. The percentage of P-cells in treatment group comparing with diabetic group was significant (p<0.05). This study showed that the protective administration of hydroalcholic extract of Urtica dioica has hypoglycemic effect and protective activity of P-cells of langerhans in hyperglycemic rats. © 2007 Asian Network for Scientific Information.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Pak. J. Biol. Sci. [Field not mapped to EPrints] C2 - 19069917 [Field not mapped to EPrints] AD - Department of Embryology and Histology, Gorgan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Pharmacology, Gorgan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Histology and Embryology, Gorgan University of Medical Sciences, P.O. Box 49175-553, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: β-cells, Hyperglycemia, Streptozotocin, Urtica dioica, plant extract, animal, article, blood, drug effect, experimental diabetes mellitus, glucose blood level, male, metabolism, methodology, pancreas islet beta cell, pathology, pathophysiology, physiology, phytotherapy, plant leaf, rat, Urtica dioica, Wistar rat, Animals, Blood Glucose, Diabetes Mellitus, Experimental, Insulin-Secreting Cells, Male, Phytotherapy, Plant Extracts, Plant Leaves, Rats, Rats, Wistar, Urtica dioica, Animalia, Rattus, Rattus norvegicus, Urtica dioica
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 05:25
Last Modified: 18 Feb 2017 05:37
URI: http://eprints.goums.ac.ir/id/eprint/2399

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