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Breast milk iodine and perchlorate concentrations in lactating Boston-area women

Pearce, E.N. and Leung, A.M. and Blount, B.C. and Bazrafshan, H.R. and He, X. and Pino, S. and Valentin-Blasini, L. and Braverman, L.E. (2007) Breast milk iodine and perchlorate concentrations in lactating Boston-area women. Journal of Clinical Endocrinology and Metabolism, 92 (5). pp. 1673-1677. ISSN 0021972X (ISSN)

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Abstract

Context: Breastfed infants rely on adequate maternal dietary iodine intake. Objective: Our objective was to measure breast milk iodine and perchlorate, an inhibitor of iodide transport into the thyroid and potentially into breast milk, in Boston-area women. Participants: The study included 57 lactating healthy volunteers in the Boston area. Measurements: Breast milk iodine and perchlorate concentrations and urine iodine, perchlorate, and cotinine concentrations were measured. For comparison, iodine and perchlorate levels in infant formulae were also measured. Results: Median breast milk iodine content in 57 samples was 155 μg/liter (range, 2.7-1968 μg/liter). Median urine iodine was 114 μg/liter (range, 25-920 μg/liter). Perchlorate was detectable in all 49 breast milk samples (range, 1.3-411 μg/liter), all 56 urine samples (range, 0.37-127 μg/liter), and all 17 infant formula samples (range, 0.22-4.1 μg/liter) measured. Breast milk iodine content was significantly correlated with urinary iodine per gram creatinine and urinary cotinine but was not significantly correlated with breast milk or urinary perchlorate. Conclusions: Perchlorate exposure was not significantly correlated with breast milk iodine concentrations. Perchlorate was detectable in infant formula but at lower levels than in breast milk. Forty-seven percent of women sampled may have been providing breast milk with insufficient iodine to meet infants' requirements. Copyright © 2007 by The Endocrine Society.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Clin. Endocrinol. Metab. [Field not mapped to EPrints] C2 - 17311853 [Field not mapped to EPrints] AD - Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, United States [Field not mapped to EPrints] AD - Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States [Field not mapped to EPrints] AD - Department of Medicine, Golestan University Medical School, Golestan, Iran [Field not mapped to EPrints] AD - Boston Medical Center, 88 East Newton Street, Evans 201, Boston, MA 02118, United States [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: cotinine, iodide, iodine, perchlorate, perchloric acid, adult, article, artificial milk, breast milk, comparative study, concentration (parameters), controlled study, female, human, lactation, maternal nutrition, measurement, normal human, priority journal, thyroid gland, urinalysis, baby food, breast milk, chemistry, diet, infant, infant nutrition, metabolism, middle aged, newborn, physiology, smoking, United States, urine, Adult, Boston, Diet, Female, Humans, Infant, Infant Food, Infant Nutrition Physiology, Infant, Newborn, Iodine, Lactation, Middle Aged, Milk, Human, Perchloric Acid, Smoking
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 08:47
Last Modified: 11 Feb 2017 06:59
URI: http://eprints.goums.ac.ir/id/eprint/2395

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