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The efficacy of ethanolic extract of lemon verbena on the skin infection due to Staphylococcus aureus in an animal model

Ghaemi, E.O. and Khorshidi, D. and Moradi, A. and Seifi, A. and Mazendrani, M. and Bazouri, M. and Mansourian, A.R. (2007) The efficacy of ethanolic extract of lemon verbena on the skin infection due to Staphylococcus aureus in an animal model. Pakistan Journal of Biological Sciences, 10 (22). pp. 4132-4135. ISSN 10288880 (ISSN)

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Abstract

Daily increasing of Staphylococcus aureus resistance to various antibiotics in particular penicillin and Methecilin has led the scientist to look fore new medicines in this area. In an in vitro laboratory studies, it has been demonstrated that ethanolic extract of Lemon verbena can prevent the growth of Staphylococcus aureus. In this study the efficacy of ethanolic extract of Lemon verbena against Staphylococcus aureus skin infection were assessed in an in vivo, in animal model. 200λ of Staphylococcus aureus suspension, were inoculated intradermally on the shoulder of 63 laboratory 20-30 g mice. the mice were divided in to 4 groups, 2 control groups: Negative (without treatment) and positive(treated with Mupirucin) and 2 test groups that treated for 7 days by ointment prepared from ethanolic extract of Lemon verbena (group3), or injection of Lemon verbena solution (group 4). The status of wounds, the rate of recovery was studied and the presence of local pus after dissection of mice on day 8 recorded and compared with each other. The wound appearance in the second day, on the injection site of S. aureus, in Group 1, 4, 3 and 2 were 84.2, 66.7, 46.2 and 23.1%, respectively. In the final day, the lesion still was remained in 78.9, 23.1, 92.3 and 77.7% in groups 1 -4, respectively. The necrotic and wide wounds were more observed in groups 1 and 3 vs two other groups. The results from this investigation indicate that the ointment prepared from ethanolic extract of Lemon verbena is a proper medication to prevent the skin infection by Staphylococcus aureus in early phase. © 2007 Asian Network for Scientific Information.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Pak. J. Biol. Sci. [Field not mapped to EPrints] C2 - 19090293 [Field not mapped to EPrints] AD - Golestan University of Medical Sciences, Iran [Field not mapped to EPrints] AD - Lahijan Azad University, Iran [Field not mapped to EPrints] AD - Gorgan Azad University, Iran [Field not mapped to EPrints] AD - Department of Microbiology, Medicine Faculty, Golestan University, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Animal model, Ethanolic extract, Lemon verbena, Skin infection, Staphylococcus aureus, alcohol, plant extract, topical antiinfective agent, animal, article, disease model, drug effect, male, metabolism, microbiology, mouse, staphylococcal skin infection, Staphylococcus aureus, treatment outcome, Verbenaceae, wound healing, wound infection, Animals, Anti-Infective Agents, Local, Disease Models, Animal, Ethanol, Male, Mice, Plant Extracts, Staphylococcal Skin Infections, Staphylococcus aureus, Treatment Outcome, Verbena, Wound Healing, Wound Infection, Animalia, Citrus limon, Mus, Staphylococcus aureus, Verbena, Verbenaceae
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 05:20
Last Modified: 18 Feb 2017 05:21
URI: http://eprints.goums.ac.ir/id/eprint/2363

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