Golestan University of Medical Sciences Repository

Effect of lead intoxication and D-penicillamine treatment on hematological indices in rats

Golalipour, M.J. and Roshandel, D. and Roshandel, G. and Ghafari, S. and Kalavi, M. and Kalavi, K. (2007) Effect of lead intoxication and D-penicillamine treatment on hematological indices in rats. International Journal of Morphology, 25 (4). pp. 717-722. ISSN 07179367 (ISSN)

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Abstract

Lead is one of the most important environmental pollution which is toxic to many organ systems. D-penicillamine (D-P) is a chelator drug which is used for treatment of lead toxicity for several years. This study was conducted in order to evaluate the efficacy of D-P in reducing the effects of lead on hematological indices. This study was done on 36 male adult, 6-8 weeks albino Wistar rats in Gorgan University of Medical Sciences. At first male adult rats were exposed to lead acetate in their drinking water. After 8 weeks, 6 rats were selected and blood samples were prepared to assess the effects of lead toxicity. The remained lead exposed rats were divided into recovery and treatment groups where distilled water and D-P was administered for them, respectively. After lead exposure, red blood cell count increased slightly, but hemoglobin and hematocrite were decreased. Also MCV and MCH were significantly decreased (P<0.05). RDW, PDW and MPV were significantly higher in lead exposed rats (P<0.05). After recovery period, most of parameters were close to normal while there were no significant differences between recovery and treatment groups. This study showed that hematologic effects of lead are reversible and D-P administration do not play an important role in subchronic lead intoxication.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Int. J. Morphol. [Field not mapped to EPrints] AD - Department of Anatomical Sciences, Gorgan University of Medical Sciences, Iran [Field not mapped to EPrints] AD - Department of Hematology and Immunology, Gorgan University of Medical Sciences, Iran [Field not mapped to EPrints] AD - Department of Anatomical Sciences, Gorgan University of Medical Sciences, P. O. Box: 49175-553, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Blood indices, D-penicillamine, Lead toxicity, Rat, Recovery
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 05:17
Last Modified: 11 Feb 2017 08:39
URI: http://eprints.goums.ac.ir/id/eprint/2360

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