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The effect of spatial learning on the number of astrocytes in the CA3 subfield of the rat hippocampus

Jahanshahi, M. and Sadeghi, Y. and Hosseini, A. and Naghdi, N. and Marjani, A. (2008) The effect of spatial learning on the number of astrocytes in the CA3 subfield of the rat hippocampus. Singapore Medical Journal, 49 (5). pp. 388-391. ISSN 00375675 (ISSN)

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Abstract

Introduction: Astrocytes play an important role in the hippocampus, probably in memory and learning. The aim of this study was to evaluate the number of astrocytes in the CA3 subfield of the rat hippocampus after spatial learning using the Morris water maze with reference and working memory methods. Methods: 45 male albino wistar rats were divided into three groups, with 15 rats in the control group and 15 rats in each of the other two groups. The two study groups of rats underwent spatial learning using the Morris water maze, with one group trained using the reference memory and the other, the working memory technique, respectively. After histological processing, the slides of the brains were stained with the phosphotanguestic acid haematoxylin staining method for detection of the astrocytes. Results: There was a significant difference in the number of astrocytes in the CA3 area between the control and reference memory groups. The difference between control and working memory groups was significant as well. Additionally, when comparing the two learning groups, we also found significant differences between them. Conclusion: The number of astrocytes increased due to spatial learning.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Singapore Med. J. [Field not mapped to EPrints] C2 - 18465048 [Field not mapped to EPrints] AD - Department of Anatomy, Gorgan University of Medical Sciences, PO Box 49175-553, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Biochemistry [Field not mapped to EPrints] AD - Cellular and Molecular Research Center, Department of Anatomy, Shahid Beheshti University of Medical Sciences, Daneshjoo Avenue, Velenjak, Tehran, Iran [Field not mapped to EPrints] AD - Department of Physiology, Pasteur Institute, Pasteur Street, Pasteur Square, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Astrocytes, CA3 subfield, Hippocampus, Morris water maze technique, Spatial learning, animal cell, animal experiment, animal tissue, article, astrocyte, brain tissue, cell count, controlled study, hippocampus, learning, male, maze test, neurobiology, nonhuman, rat, reference memory, staining, working memory, Animals, Astrocytes, Hippocampus, Male, Maze Learning, Rats, Rats, Wistar
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 05:19
Last Modified: 26 Feb 2017 09:27
URI: http://eprints.goums.ac.ir/id/eprint/2334

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