Golestan University of Medical Sciences Repository

Rats with hippocampal lesion show impaired learning and memory in the ziggurat task: A new task to evaluate spatial behavior

Faraji, J. and Lehmann, H. and Metz, G.A. and Sutherland, R.J. (2008) Rats with hippocampal lesion show impaired learning and memory in the ziggurat task: A new task to evaluate spatial behavior. Behavioural Brain Research, 189 (1). pp. 17-31. ISSN 01664328 (ISSN)

[img]
Preview
PDF - Published Version
Download (1MB) | Preview

Abstract

Spatial tasks are widely used to determine the function of limbic system structures in rats. The present study used a new task designed to evaluate spatial behavior, the ziggurat task (ZT), to examine the performance of rats with widespread hippocampal damage induced by N-methyl-d-aspartic acid (NMDA). The task consisted of an open field containing 16 identical ziggurats (pyramid shaped towers) arranged at equal distances. One of the ziggurats was baited with a food reward. The task required rats to navigate through the open field by using a combination of distal and/or proximal cues in order to locate the food reward. The ability to acquire and recall the location of the goal (baited) ziggurat was tested in consecutive training sessions of eight trials per day for 10 days. The location of the goal ziggurat was changed every second day, requiring the rats to learn a total of five different locations. Several parameters, including latency to find the target, distance traveled, the number of visits to non-baited ziggurats (errors), and the number of returns were used as indices of learning and memory. Control rats showed a significant decrease in distance traveled and reduced latency in locating the goal ziggurat across trials and days, suggesting that they learned and remembered the location of the goal ziggurat. Interestingly, the hippocampal-damaged group moved significantly faster, and traveled longer distances compared to the control group. Significant differences were observed between these groups with respect to the number of errors and returns on test days. Day 11 served as probe day, in which no food reward was given. The controls spent more time searching for the food in the previous training quadrant compared to the hippocampal group. The findings demonstrate that the ZT is a sensitive and efficient dry task for measuring hippocampus-dependent spatial performance in rats requiring little training and not associated with some of the disadvantages of water tasks. © 2007 Elsevier B.V. All rights reserved.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Behav. Brain Res. [Field not mapped to EPrints] C2 - 18192033 [Field not mapped to EPrints] AD - Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada [Field not mapped to EPrints] AD - Health Department, Golestan University of Medical Sciences, P.O. Box 49165-568, Gorgan, Iran [Field not mapped to EPrints] AD - Psychology Department, Trent University, Peterborough, Ont. K9J 7B8, Canada [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Amnesia, Damage, Hippocampus, Navigation, Spatial performance, n methyl dextro aspartic acid, amnesia, animal experiment, animal model, article, behavior, brain injury, controlled study, hippocampus, learning disorder, male, memory disorder, nonhuman, open field behavior, open field test, parameter, priority journal, rat, recall, reward, task performance, Animals, Association Learning, Behavioral Research, Exploratory Behavior, Goals, Hippocampus, Male, Maze Learning, Memory, N-Methylaspartate, Nerve Degeneration, Neurons, Neurotoxins, Orientation, Rats, Rats, Long-Evans, Reaction Time, Space Perception, Spatial Behavior
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 10:01
Last Modified: 26 Feb 2017 08:02
URI: http://eprints.goums.ac.ir/id/eprint/2333

Actions (login required)

View Item View Item