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Ouabaine like effects of ethanolic extract of aerial parts of Urtica dioica L. on isolated rabbit atrioventricular node: Potential role as an anti-arrhythmic plant

Khori, V. and Naebpour, M. and Mir-Abbasi, A. (2008) Ouabaine like effects of ethanolic extract of aerial parts of Urtica dioica L. on isolated rabbit atrioventricular node: Potential role as an anti-arrhythmic plant. Journal of Medicinal Plants, 7 (26). 24-32+101. ISSN 16840240 (ISSN)

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Abstract

Bachground: The ideal drug for treatment of wide range of supraventricular arrhythmia has yet to be developed. For cardiovascular disease, herbal treatments are suitable alternatives for synthetic drugs due to their availability, minimal side effects and lower price. Previous studies showed antihypertensive, negative inotropic activities of Urtica dioica (Nettle). Objectives: The aims of the present study were: 1) to determine concentration-dependent effects of ethanolic extract of nettle on the nodal basic and functional properties. 2) to campare mechanism of action nettel with ouabaine. Method: Male Newsland rabbits (1-1.3 kg) were used in all of experiments; various experimental stimulating protocols (WBCL; Recovery, Facilitation, Fatigue) were applied to assessing electrophysiological properties of Node. We used isolated perfused AV-nodal preparation (n=24). All protocols were repeated in the presence and absence (control) of different concentration (0.25 - 0.5-1 g/l) of Nettle and ouabaine(0.1μM). Results were shown as Mean ± SE and a probability of 5% was taken to indicate statistical significance. Results: We had considerable depression in basic and functional properties of node after adding Nettle, as WBCL, Effective refractory period, Functional refractory period and nodal conduction Time significantly increased(p<0.05). In addition magnitude of fatigue (ΔAH) and ΔFRP (Amount of facilitation) significantly increased (p<0.05). Conclusion: The above results showed potential antiarrhythmic properties of "Urtica dioica" by increasing fatigue and nodal refractoriness. Therefore, it may be considered for treatment of supraventicular arrhythmias.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - Persian [Field not mapped to EPrints] J2 - J. Med. Plants [Field not mapped to EPrints] AD - Pharmacology Department, Cardiovascular Rsearch Center, Golestan University of Medical Sciences, Golestan, Iran [Field not mapped to EPrints] AD - Pharmacology Department, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Cardiovascular Rsearch Center, Golestan University of Medical Sciences, Golestan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Arrhythmia, AV-Node, Functional properties, Urtica dioica, ouabain, Urtica dioica extract, animal experiment, animal tissue, article, atrioventricular conduction, controlled study, dose response, drug activity, drug effect, heart atrioventricular node, heart muscle refractory period, male, nonhuman, rabbit, refractory period, supraventricular tachycardia, Urtica dioica, Oryctolagus cuniculus, Urtica, Urtica dioica
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 06:20
Last Modified: 26 Feb 2017 06:42
URI: http://eprints.goums.ac.ir/id/eprint/2331

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