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Maternal smoking during pregnancy, other prenatal and perinatal factors, and the risk of Legg-Calvé-Perthes disease

Bahmanyar, S. and Montgomery, S.M. and Weiss, R.J. and Ekbom, A. (2008) Maternal smoking during pregnancy, other prenatal and perinatal factors, and the risk of Legg-Calvé-Perthes disease. Pediatrics, 122 (2). e459-e464. ISSN 00314005 (ISSN)

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Abstract

OBJECTIVE. The causes of Legg-Calvé-Perthes disease are largely unknown, but this pediatric disease seems to result from interruption of the blood supply to the proximal femur and is considered a vascular disease. Because maternal smoking during pregnancy influences fetal development and is associated with cardiovascular diseases in offspring, we hypothesized that this exposure is a risk for Legg-Calvé- Perthes disease and also investigated other markers of impaired fetal development and early-life exposures. MATERIALS AND METHODS. The Swedish Inpatient Register identified 852 individuals with a diagnosis of Legg-Calvé-Perthes disease from 1983 to 2005, individually matched by year of birth, age, sex, and region of residence with 4432 randomly selected control subjects. Linkage with the Swedish Medical Birth Register provided information on prenatal factors, including maternal smoking. Conditional logistic regression examined associations of maternal smoking during pregnancy and the other measures with the risk of Legg-Calvé-Perthes disease in offspring, adjusted for socioeconomic index and other potential confounding factors. RESULTS. Maternal smoking during pregnancy was associated with an increased Legg-Calvé-Perthes disease risk, and heavy smoking was associated with a risk increase of almost 100%. Very low birth weight and cesarean section were independently associated with ̃240% and 36% increases in the risk of Legg-Calvé-Perthes disease, respectively. CONCLUSION. Maternal smoking during pregnancy and other factors indicated by impaired fetal development may be associated with an increased risk of Legg-Calvé- Perthes disease.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Pediatrics [Field not mapped to EPrints] C2 - 18625663 [Field not mapped to EPrints] AD - Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden [Field not mapped to EPrints] AD - Section of Orthopaedics and Sports Medicine, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden [Field not mapped to EPrints] AD - Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Clinical Research Centre, Örebro University Hospital, Örebro, Sweden [Field not mapped to EPrints] AD - Department of Primary Care and Social Medicine, Charing Cross Hospital, Imperial College, London, United Kingdom [Field not mapped to EPrints] AD - Karolinska Hospital, Epidemiology Unit, Department of Medicine, M9:01,171 76 Stockholm, Sweden [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Legg-Perthes disease, Maternal smoking, Passive smoking, Risk factors, abortion, adolescent, Apgar score, article, body height, bone blood flow, cardiovascular disease, cesarean section, child, controlled study, female, femur, gestational age, head circumference, human, major clinical study, male, maternal age, maternal smoking, passive smoking, perinatal period, Perthes disease, prenatal exposure, priority journal, register, risk factor, small for date infant, socioeconomics, statistical analysis, stillbirth, Sweden, very low birth weight, age distribution, birth weight, case control study, comorbidity, confidence interval, environmental exposure, epidemiology, follow up, hospitalization, incidence, infant, onset age, pathophysiology, Perthes disease, pregnancy, prenatal exposure, preschool child, probability, reference value, retrospective study, risk, risk assessment, sex ratio, smoking, statistical model, statistics, Sweden, Adolescent, Age Distribution, Age of Onset, Birth Weight, Case-Control Studies, Causality, Child, Child, Preschool, Comorbidity, Confidence Intervals, Female, Follow-Up Studies, Gestational Age, Humans, Incidence, Infant, Legg-Perthes Disease, Logistic Models, Male, Maternal Exposure, Odds Ratio, Pregnancy, Prenatal Exposure Delayed Effects, Probability, Reference Values, Retrospective Studies, Risk Assessment, Severity of Illness Index, Sex Distribution, Smoking, Sweden
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 08:05
Last Modified: 26 Feb 2017 05:08
URI: http://eprints.goums.ac.ir/id/eprint/2323

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