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The granule cell density of the dentate gyrus following administration of Urtica dioica extract to young diabetic rats

Fazeli, S.A. and Gharravi, A.M. and Ghafari, S. and Jahanshahi, M. and Golalipour, M.J. (2008) The granule cell density of the dentate gyrus following administration of Urtica dioica extract to young diabetic rats. Folia Morphologica, 67 (3). pp. 196-204. ISSN 00155659 (ISSN)

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Abstract

Urtica dioica L. Stinging nettle has long been known worldwide as a medicinal plant. To study the benefits of the nettle in diabetic encephalopathy, the granule cell density of the dentate gyrus of diabetic rats was studied following administration of Urtica dioica extract. A total of 24 male albino Wistar rats were allocated equally to normal, diabetic, preventive and treatment groups. Hyperglycaemia was induced by streptozotocin (80 mg/kg) in the animals of the diabetic and treatment groups. One week after injection of the streptozotocin the animals in the treatment group received a hydroalcoholic extract of Urtica dioica (100 mg/kg/day) for 4 weeks intraperitoneally. The rats of the preventive group received hydroalcoholic extract of U. dioica (100 mg/kg/day) IP for the first 5 days and an injection of streptozotocin (80 mg/kg) on the 6th day. After 5 weeks of study all the rats were sacrificed and coronal sections were taken from the dorsal hippocampal formation of the right cerebral hemispheres and stained with cresyl violet. The area densities of the granule cells were measured and compared in the four groups. The density was lower in the diabetic rats compared with the controls (p > 0.05). The preventive group showed lower cell density than the controls (p > 0.05). The densities in the treated rats were higher than in the diabetic rats (p > 0.05). Furthermore, the control and treated rats showed similar densities (p > 0.05). It seems that U. dioica extract can help compensate for granule cell loss in the diabetic rat dentate gyrus, which can ameliorate cognitive impairment in diabetes. However, preventive use of the extract showed no significant benefit. Copyright © 2008 Via Medica.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Folia Morphol. [Field not mapped to EPrints] C2 - 18828102 [Field not mapped to EPrints] AD - Department of Embryology and Histology, Gorgan University of Medical Sciences, P.O. Box 49175-553, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Dentate gyrus, Diabetes, Granule cell density, Rat, Urtica dioica, streptozocin, Urtica dioica extract, animal cell, animal experiment, animal model, article, cell density, cell loss, cognitive defect, controlled study, cresyl violet staining, dentate gyrus, diabetes mellitus, granule cell, hippocampus, hyperglycemia, male, neuroprotection, nonhuman, rat, right hemisphere, solvent extraction, staining, streptozocin diabetes, Wistar rat, Animals, Blood Glucose, Cell Count, Cognition Disorders, Dentate Gyrus, Diabetes Mellitus, Experimental, Diabetic Neuropathies, Disease Models, Animal, Glucose Tolerance Test, Male, Multivariate Analysis, Plant Extracts, Rats, Rats, Wistar, Streptozocin, Urtica dioica, Animalia, Rattus, Rattus norvegicus, Urtica, Urtica dioica
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 04:22
Last Modified: 26 Feb 2017 09:48
URI: http://eprints.goums.ac.ir/id/eprint/2321

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