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Heterotopic pregnancy following ovulation induction by Clomiphene and a healthy live birth: A case report

Honarbakhsh, A. and Khoori, E. and Mousavi, S. (2008) Heterotopic pregnancy following ovulation induction by Clomiphene and a healthy live birth: A case report. Journal of Medical Case Reports, 2. ISSN 17521947 (ISSN)

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Introduction: A heterotopic pregnancy is defined as the presence of a combined intrauterine and ectopic pregnancy. Its estimated incidence is accepted as between 1/7000 and 1/30,000 pregnancies. It is also reported to be as high as 1% after the use of assisted reproductive technology, but Clomiphene Citrate which increases the rate of twinning, could be associated with a heterotopic pregnancy rate of 1/900, which is much less than using assisted reproductive technology. Heterotopic pregnancies are diagnostic and therapeutic challenges for obstetricians. If they continue without diagnosis, a life-threatening situation may occur even when surgical intervention with laparotomy is performed. Case presentation: We present the case of a 22-year-old Iranian woman who developed a simultaneous extra -and intrauterine pregnancy after the induction of ovulation with Clomiphene. In this case, there was a delay in the detection of the ectopic pregnancy component resulting in an emergency laparotomy being performed. Fortunately after the laparotomy, the intrauterine pregnancy was not affected and it progressed satisfactorily until 37 weeks. A healthy male baby was delivered by caesarean section. Conclusion: This case suggests that a heterotopic pregnancy must always be considered in patients presenting with pelvic pain even in a confirmed intrauterine pregnancy, particularly after the induction of ovulation by Clomiphene Citrate or assisted reproductive technology. Every clinician treating women of reproductive age should keep this diagnosis in mind. It also demonstrates that early diagnosis is essential in order to salvage the intrauterine pregnancy and avoid maternal morbidity and mortality. © 2008 Honarbakhsh et al; licensee BioMed Central Ltd.

Item Type: Article
Additional Information: Unmapped bibliographic data: C7 - 390 [EPrints field already has value set] LA - English [Field not mapped to EPrints] J2 - J. Med. Case Rep. [Field not mapped to EPrints] AD - Department of Radiology and Ultrasonography, Madaen Hospital, Tehran, Iran [Field not mapped to EPrints] AD - Department of Midwifery, Golestan University of Medical Sciences, PO Box 49165-568, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Obstetrics and Gynaecology, Madaen Hospital, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: clomifene citrate, adult, article, case report, cesarean section, childbirth, clinical feature, ectopic pregnancy, female, female infertility, gestation period, histopathology, hospital discharge, hospitalization, human, Iran, live birth, nullipara, ovulation induction, patient referral, pregnancy outcome, priority journal, salpingectomy
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 05:37
Last Modified: 25 Feb 2017 09:10
URI: http://eprints.goums.ac.ir/id/eprint/2300

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