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Role of slow pathway after nodal fast pathway ablation on the basic and rate-dependent properties of the isolated rabbit atrioventricular node

Khori, V. and Nayebpour, M. and Mirabbasi, A. and Pourabouk, M. (2009) Role of slow pathway after nodal fast pathway ablation on the basic and rate-dependent properties of the isolated rabbit atrioventricular node. Physiology and Pharmacology, 13 (1). pp. 28-36. ISSN 17350581 (ISSN)

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Abstract

Introduction: The aim of this study was to obtain new insights into the possible relations between functional properties of slow concealed pathway and rate-dependent properties of the AV-node. Methods: Rate-dependent nodal properties of recovery, facilitation, and fatigue were characterized by stimulation protocols in one group of isolated superfused AV-Nodal rabbits (n=7). Small miniature lesions were made by delivering constant voltage (110 V-100 s) with unipolar silver electrode. Results: Fast pathway ablation significantly decreased facilitation and had no effect on fatigue and nodal refractoriness. The most important effect of fast pathway ablation was prolongation of the minimum conduction time. Conclusion: The FP-ablation revealed the presence of the concealed SP. Rate-dependent property of the node is dependent to dynamic interaction between concealed slow with slow pathway. The fast pathway was involved in the mechanism of facilitation.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - Persian [Field not mapped to EPrints] J2 - Physiol. Pharmacol. [Field not mapped to EPrints] AD - Golestan Cardiovascular Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Dept. Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Ablation, Arrhythmia, AV node, Fast pathway, article, controlled study, electric potential, electrode, facilitation, fatigue, heart atrioventricular node, nerve conduction, nonhuman, rabbit, stimulation
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 04:07
Last Modified: 01 Mar 2017 06:22
URI: http://eprints.goums.ac.ir/id/eprint/2293

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