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Cancer risk among patients with multiple sclerosis and their parents

Bahmanyar, S. and Montgomery, S.M. and Hillert, J. and Ekbom, A. and Olsson, T. (2009) Cancer risk among patients with multiple sclerosis and their parents. Neurology, 72 (13). pp. 1170-1177. ISSN 00283878 (ISSN)

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Abstract

Background: We investigated cancer risk among patients with multiple sclerosis (MS) and whether variation by age at MS diagnosis helps to elucidate mechanisms underlying the previously reported reduced cancer risk. We also studied cancer risk among parents to ascertain if MS susceptibility genes may confer protection against cancer in relatives. Methods: Cox proportional hazards regression, adjusted for age, sex, area, and socioeconomic index, estimated cancer risk among 20,276 patients with MS and 203,951 individuals without MS, using Swedish general population register data. Similar analyses were conducted among 11,284 fathers and 12,006 mothers of patients with MS, compared with 123,158 fathers and 129,409 mothers of controls. Results: With an average of 35 years of follow-up, there was a decreased overall cancer risk among patients with MS (hazard ratio = 0.91, 0.87-0.95). Increased risks were observed for brain tumors (1.44, 1.21-1.72) and urinary organ cancer (1.27, 1.05-1.53). Parents of patients with MS did not have a notably increased or decreased overall cancer risk. Conclusions: The reduction in cancer risk in patients with multiple sclerosis (MS) may result from behavioral change, treatment, or we speculate that some immunologic characteristics of MS disease activity improve antitumor surveillance. The lack of association among parents indicatesthat a simple inherited characteristic is unlikely to explain the reduced cancer risk among patients with MS. MS is associated with increased risk for some cancers, such as of urinary organs and brain tumors (although surveillance bias may be responsible). copyright © by AAN Enterprises, Inc.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Neurology [Field not mapped to EPrints] C2 - 19332695 [Field not mapped to EPrints] AD - Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, SE-171 76 Stockholm, Sweden [Field not mapped to EPrints] AD - Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden [Field not mapped to EPrints] AD - Department of Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden [Field not mapped to EPrints] AD - Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Clinical Research Centre, � Rebro University Hospital, � Rebro, Sweden [Field not mapped to EPrints] AD - Department of Primary Care and Social Medicine, Charing Cross Hospital, Imperial College, London, United Kingdom [Field not mapped to EPrints] AD - Department of Clinical Neuroscience, Division of Neurology, Karolinska Institutet, Stockholm, Sweden [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: adolescent, adult, age distribution, aged, article, behavior change, brain tumor, cancer registry, cancer risk, child, controlled study, female, follow up, genetic susceptibility, human, immunosurveillance, inheritance, major clinical study, male, multiple sclerosis, parent, priority journal, proportional hazards model, Sweden, urinary tract cancer, comparative study, genetic predisposition, genetics, middle aged, multiple sclerosis, neoplasm, parent, register, risk factor, Sweden, Adolescent, Adult, Aged, Aged, 80 and over, Child, Female, Follow-Up Studies, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Multiple Sclerosis, Neoplasms, Parents, Registries, Risk Factors, Sweden, Young Adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 05:51
Last Modified: 01 Mar 2017 08:03
URI: http://eprints.goums.ac.ir/id/eprint/2287

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