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Attenuation of serum laminin concentrations upon treatment of chronic hepatitis

Parsian, H. and Nouri, M. and Soumi, M.H. and Rahimipour, A. and Qujeq, D. and Estakhri, R. and Kashifard, M. and Agcheli, K. and Majidi, G. (2009) Attenuation of serum laminin concentrations upon treatment of chronic hepatitis. New Zealand Journal of Medical Laboratory Science, 63 (1). pp. 12-17. ISSN 11710195 (ISSN)

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Abstract

Objectives: The aim of this work was to determine the serum laminin level cutoff point for predicting liver fibrosis highlighting its diagnostic value and determining the effect of treatment on serum laminin concentrations. Methods: Serum laminin concentrations in chronic hepatitis patients (n=62) and controls (n=20) were compared by ELISA and stages of fibrosis were assessed according to the modified Knodell score system. Results: Mean serum laminin concentration in patients (91.9 ± 20.9 ng/ml) was greater than controls (46.2 ± 10.2 ng/ml; p <0.001). Serum concentrations of laminin in all stages of hepatic fibrosis were significantly higher than those of healthy controls (p <0.05). A cutoff point of 52ng laminin/ml of serum was obtained for the discrimination of various stages of liver fibrosis showing a good sensitivity (96.8%) and specificity (80%). After 6 months of treatment, a gradual decrease in serum laminin concentrations were observed, however the level was still higher than that of the healthy group (p<0.05). Conclusions: Our findings suggest that the serum laminin concentration is a useful noninvasive marker of liver fibrosis and shows a strong positive correlation with different stages of the disease.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - New Zealand J. Med. Lab. Sci. [Field not mapped to EPrints] AD - Gastroenterology Research Centre, Tabriz University of Medical Sciences, Daneshgah Avenue, Tabriz, Iran [Field not mapped to EPrints] AD - Department of Biochemistry, Tabriz University of Medical Sciences, Tabriz, Iran [Field not mapped to EPrints] AD - Department of Biochemistry and Biophysics, Babol University of Medical Sciences, Babol, Iran [Field not mapped to EPrints] AD - Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran [Field not mapped to EPrints] AD - Yahya Nezhad Hospital, Babol University of Medical Sciences, Babol, Iran [Field not mapped to EPrints] AD - Gastroenterology Research Centre, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Chronic hepatitis, Hepatic fibrosis, Laminin, Treatment, adefovir, azathioprine, interferon, laminin, peginterferon, prednisolone, ribavirin, adolescent, adult, aged, article, autoimmune hepatitis, blood level, chronic hepatitis, controlled study, diagnostic value, disease marker, female, hepatitis B, hepatitis C, human, liver fibrosis, major clinical study, male, non invasive measurement, normal value, sensitivity and specificity
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 06:00
Last Modified: 01 Mar 2017 07:23
URI: http://eprints.goums.ac.ir/id/eprint/2285

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