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The effect of Urtica dioica extract on the number of astrocytes in the dentate gyrus of diabetic rats

Jahanshahi, M. and Golalipour, M.J. and Afshar, M. (2009) The effect of Urtica dioica extract on the number of astrocytes in the dentate gyrus of diabetic rats. Folia Morphologica, 68 (2). pp. 93-97. ISSN 00155659 (ISSN)

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Diabetes mellitus is associated with cerebral alterations in both human and animal models of the disease. These alterations include abnormal expression of hypothalamic neuropeptides and hippocampal astrogliosis. Urtica dioica (Nettle) is among several species listed for their use against diabetes in folk medicine. The aim of this study was the evaluation of the astrocyte number in the dentate gyrus of diabetic rats after treatment with nettle. A total of 21 male albino Wistar rats were used in the present study. The animals were divided into three groups: control, nettle-untreated diabetic, and nettle treated diabetic. Hyperglycaemia was induced by streptozotocin (80 mg/kg) in the animals of the diabetic and treatment groups. One week after injection of the streptozotocin, the animals in the treatment group received a hydroalcoholic extract of Urtica dioica (100 mg/kg/day) for 4 weeks intraperitoneally. After a 5-week survival period, all the rats were sacrificed and coronal sections were taken from the dorsal hippocampal formation of the right cerebral hemispheres. The area densities of the astrocytes were measured and compared between the three groups (p < 0.05). The number of astrocytes increased in the diabetic rats (24.06 ± 9.57) compared with the controls (17.52 ± 6.66). The densities in the treated rats (19.50 ± 6.16) were lower than in the diabetic rats. Furthermore, the control and treated rats showed similar densities. We concluded that U. dioica extract helped compensate for astrocytes in the treatment rats dentate gyrus in comparison with diabetic rats. Copyright © 2009 Via Medica.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Folia Morphol. [Field not mapped to EPrints] C2 - 19449296 [Field not mapped to EPrints] AD - Department of Anatomy, Gorgan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Anatomy, Birjand University of Medical Sciences, Birjand, Iran [Field not mapped to EPrints] AD - Department of Anatomy, Faculty of Medicine, Gorgan University of Medical Sciences, km 4 Gorgan-Sari road (Shastcola), Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Astrocyte, Dentate gyrus, Diabetes, Urtica dioica, streptozocin, Urtica dioica extract, animal experiment, animal model, animal tissue, article, astrocyte, brain tissue, cell count, controlled study, dentate gyrus, drug effect, drug mechanism, drug synthesis, hemisphere, hippocampus, hyperglycemia, male, nonhuman, rat, streptozocin diabetes, survival time, tissue section, treatment duration, treatment outcome, Wistar rat, Animals, Astrocytes, Blood Glucose, Dentate Gyrus, Diabetes Mellitus, Experimental, Hyperglycemia, Male, Plant Extracts, Rats, Rats, Wistar, Streptozocin, Urtica dioica, Animalia, Rattus, Rattus norvegicus, Urtica, Urtica dioica
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 04:23
Last Modified: 04 Mar 2017 10:44
URI: http://eprints.goums.ac.ir/id/eprint/2279

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