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Echinacea purpurea polysaccharide reduces the latency rate in herpes simplex virus type-1 infections

Ghaemi, A. and Soleimanjahi, H. and Gill, P. and Arefian, E. and Soudi, S. and Hassan, Z. (2009) Echinacea purpurea polysaccharide reduces the latency rate in herpes simplex virus type-1 infections. Intervirology, 52 (1). pp. 29-34. ISSN 03005526 (ISSN)

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Abstract

Objective: During the latency period of herpes simplex virus type-1 (HSV-1), the virus can occasionally reactivate, travel back to the eye and cause recurrent ocular disease. As this condition arises from the ability of HSV-1 to produce a dormant infection, effective medication to prevent the virus enter a latent state should prevent it. In this study, we applied Echinacea polysaccharide (EP) fraction as prophylactic mediator for latency prevention. Methods: In order to investigate the protective properties of EP, we evaluated its immunostimulatory functions on different immune aspects that play important roles in latency prevention (particularly IFN-γ as one of the main indicators of cellular immunity and latency). Finally, we assessed establishment of latency by detection of thymidine kinase gene in trigeminal ganglia of BALB/c mice. Results: We demonstrated that EP promotes immune response, leading to a reduced latency rate, and it has a promising effect on latency prevention. Conclusion: EP was able to exert an antiviral action on the development of recurrent HSV-1 disease when supplied prior to infection. © 2009 S. Karger AG, Basel.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Intervirology [Field not mapped to EPrints] C2 - 19372701 [Field not mapped to EPrints] AD - Faculty of Medicine, Golestan University of Medical Sciences and Health Care, Gorgan, Iran [Field not mapped to EPrints] AD - Young Researchers' Club, Tehran Science and Research Campus, IAU, Tehran, Iran [Field not mapped to EPrints] AD - Department of Nanobiotechnology, Faculty of Basic Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Department of Virology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran [Field not mapped to EPrints] AD - Department of Immunology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran [Field not mapped to EPrints] AD - Department of Virology, School of Medical Sciences, Tarbiat Modares University, P.O. Box 14115-111, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Echinacea polysaccharide fraction, Herpes simplex virus type-1, Immunostimulation, Latency, Trigeminal ganglion, gamma interferon, polysaccharide, thymidine kinase, animal experiment, animal model, antiviral activity, article, Bagg albino mouse, cellular immunity, controlled study, Echinacea purpurea, female, gene, herpes simplex, Herpes simplex virus 1, immune response, immunostimulation, in vivo study, infection prevention, latent period, mouse, nonhuman, priority journal, prophylaxis, trigeminus ganglion, Animals, Corneal Diseases, DNA, Viral, Echinacea, Female, Herpes Simplex, Herpesvirus 1, Human, Humans, Interferon-gamma, Lymphocyte Activation, Mice, Phytotherapy, Plant Extracts, T-Lymphocytes, Thymidine Kinase, Trigeminal Nerve, Virus Latency, Echinacea purpurea, Human herpesvirus 1, Mus
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 05:32
Last Modified: 27 Feb 2017 07:26
URI: http://eprints.goums.ac.ir/id/eprint/2277

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