Golestan University of Medical Sciences Repository

Teratogenic effects of gabapentin on the skeletal system of Balb/C mice fetuses

Afshar, M. and Hassanzadeh-Taheri, M.M. and Moallem, S.-A. and Tamizi, A. and Golalipour, M.J. (2009) Teratogenic effects of gabapentin on the skeletal system of Balb/C mice fetuses. Neurosciences, 14 (3). pp. 239-244. ISSN 13196138 (ISSN)

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Abstract

Objectives: To evaluate the effects of gabapentin )GBP( administration on mice fetuses. Methods: This study was carried out in Birjand University of Medical Sciences during 2008. Thirty Balb/c pregnant mice were divided randomly into 3 groups: 2 experimental groups that received 25 mg/kg )I( and 50 mg/kg )II( of GBP intraperitoneally for the first 15 days of pregnancy, and a control group that received normal saline. External observations of day 18 fetuses and skeleton double staining were performed. Results: Both experimental groups showed similar disorders that can be categorized as the following: 1( decrease of fetal body weight and increase of fetal resorption, 2( macroscopic malformations, and 3( skeletal malformations. Fetal body weights were significantly lower, and fetus resorptions were significantly higher in both treated groups compared to the control group. Macroscopic malformations included exencephaly, limbs defects, brachygnathia, vertebral column deformity, and fetuses with severe retarded growth. Skeletal malformations included delayed ossification, scoliosis, calvaria deformity, and mandibular hypoplasia. Conclusion: This study revealed that GBP can induce previously unreported severe malformations if it is used continuously during the implantation, neurulation, and organogenesis stages of pregnancy. Therefore, it is suggested that great caution should be exercised in using GBP during the early stages of pregnancy until further studies are performed to better understand these effects.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Neurosciences [Field not mapped to EPrints] AD - Department of Anatomy, Birjand University of Medical Sciences, Birjand, Iran [Field not mapped to EPrints] AD - Department of Pharmacodynamics and Toxicology, Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran [Field not mapped to EPrints] AD - Department of Anatomy, Gorgan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: gabapentin, sodium chloride, animal experiment, animal model, article, bone malformation, controlled study, exencephaly, female, fetus, fetus malformation, fetus resorption, fetus weight, limb malformation, mandible hypoplasia, mouse, nonhuman, scoliosis, skeleton malformation, skull malformation, spine malformation, staining, teratogenesis
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 05:55
Last Modified: 04 Mar 2017 10:38
URI: http://eprints.goums.ac.ir/id/eprint/2268

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