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Stress and corticosterone enhance cognitive recovery from hippocampal stroke in rats

Faraji, J. and Lehmann, H. and Metz, G.A. and Sutherland, R.J. (2009) Stress and corticosterone enhance cognitive recovery from hippocampal stroke in rats. Neuroscience Letters, 462 (3). pp. 248-252. ISSN 03043940 (ISSN)

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When locally infused, the potent vasoconstrictor, endothelin-1 (ET-1) produces partial ischemic damage in many regions of the brain, including the hippocampus. The hippocampus is known for a high density of glucocorticoid receptors and for the potent actions of stress and corticosterone to modulate function. The current experiment evaluates the effects of stress and corticosterone on the severity of memory impairment and anatomical pathology produced by hippocampal mini-stroke. Rats with ET-1-induced mini-stroke were exposed to mild restraint stress (1 h/day) or oral corticosterone (0.5 mg/kg) for 16 consecutive days. Spatial memory was then tested in the Morris water task (MWT) and the ziggurat task (ZT). The groups ET-1 + stress and ET-1 + corticosterone performed significantly better in both tasks than the ET-1-only group. This suggests that increasing corticosteroid levels alleviates the hippocampal stroke-induced memory deficits. Hippocampal volumetric assessment also revealed that both the post-stroke stress and corticosteroid treatment significantly decreased the volume of hippocampal damage. The findings support the view that elevated levels of corticosterone may exert neuroprotective effects in the hippocampus following stroke. © 2009.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Neurosci. Lett. [Field not mapped to EPrints] C2 - 19607880 [Field not mapped to EPrints] AD - Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada [Field not mapped to EPrints] AD - Neuroscience Research Centre, Golestan University of Medical Sciences, P.O. Box 49165-568, Gorgan, Iran [Field not mapped to EPrints] AD - Psychology Department, Trent University, Peterborough, Ont. K9J 7B8, Canada [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Endothelin-1, Hippocampal stroke, Morris water task, Restraint stress, Ziggurat task, corticosteroid, corticosterone, endothelin 1, animal experiment, animal model, article, brain ischemia, cerebrovascular accident, controlled study, immobilization stress, male, memory disorder, neuroprotection, nonhuman, priority journal, rat, spatial memory, task performance, Animals, Cognition, Corticosterone, Endothelin-1, Hippocampus, Male, Memory, Rats, Rats, Long-Evans, Restraint, Physical, Stress, Psychological, Stroke
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 05:53
Last Modified: 17 Mar 2018 09:45
URI: http://eprints.goums.ac.ir/id/eprint/2260

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