Golestan University of Medical Sciences Repository

Polymorphism of Pro12Ala in the peroxisome proliferator-activated receptor 2 gene in Iranian diabetic and obese subjects

Mirzaei, H. and Akrami, S.M. and Golmohammadi, T. and Doosti, M. and Heshmat, R. and Nakhjavani, M. and Amiri, P. (2009) Polymorphism of Pro12Ala in the peroxisome proliferator-activated receptor 2 gene in Iranian diabetic and obese subjects. Metabolic Syndrome and Related Disorders, 7 (5). pp. 453-458. ISSN 15404196 (ISSN)

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Abstract

Background: Peroxisome proliferator-activated receptor 2 (PPAR2) is a nuclear receptor that regulates adipocyte differentiation, lipid metabolism, and insulin sensitivity. The aim of this study was to investigate the association between the Pro12Ala single nucleotide polymorphism (SNP) at the PPAR2 gene and type II diabetes (T2DM) and obesity in an Iranian population. Methods: The genomic DNA of the 312 subjects included four groups: (1) nonobese with type II diabetes, (2) obese without type II diabetes, (3) obese with type II diabetes, and (4) nondiabetic nonobese controls. The Pro12Ala polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Results: Frequencies of the Ala allele in obese subjects were significantly different from those control subjects (odds ratio [OR], 2.358; 95% confidence interval [CI], 1.101-5.05) (P = 0.025). In contrast, no significant association was detected between the Pro12Ala polymorphism and type II diabetes (OR, 0.652; 95% CI, 0.261-1.628). In all subjects, the Ala carriers had a higher body mass index (BMI) compared with the common allele. Conclusions: Our results showed that the Pro12Ala polymorphism in the PPAR2 gene is associated with obesity in Iranian subjects and the presence of the Ala allele could predict higher BMI. © 2009 Mary Ann Liebert, Inc.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Metab. Syndr. Relat. Disord. [Field not mapped to EPrints] C2 - 19558269 [Field not mapped to EPrints] AD - Department of Hygiene, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Clinical Biochemistry, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Endocrinology and Metabolism Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Medical Genetics Department, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: genomic DNA, peroxisome proliferator activated receptor gamma 2, adult, aged, allele, article, body mass, disease association, DNA polymorphism, female, gene frequency, human, Iran, major clinical study, male, non insulin dependent diabetes mellitus, obesity, priority journal, single nucleotide polymorphism, Alanine, Asian Continental Ancestry Group, Body Mass Index, Case-Control Studies, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Iran, Logistic Models, Male, Obesity, Odds Ratio, Polymorphism, Single Nucleotide, PPAR gamma, Proline, Risk Assessment, Risk Factors
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 05:27
Last Modified: 04 Mar 2017 05:09
URI: http://eprints.goums.ac.ir/id/eprint/2259

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