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Serum leptin levels and irritable bowel syndrome: A new hypothesis

Semnani, S. and Roshandel, G. and Keshtkar, A. and Najafi, L. and Amiriani, T. and Farajollahi, M. and Moradi, A. and Joshaghani, H. (2009) Serum leptin levels and irritable bowel syndrome: A new hypothesis. Journal of Clinical Gastroenterology, 43 (9). pp. 826-830. ISSN 01920790 (ISSN)

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GOALS: This study was undertaken to investigate the relationship between serum leptin levels and the development irritable bowel syndrome (IBS). BACKGROUND: Stress has been known as an important causative factor in IBS. Various studies have indicated the relationship between serum leptin levels and stress levels. So searching the relationship between the production and level of this hormone and development of IBS may help to understand the pathophysiology of the disease. STUDY: This was a case-control study. Eighty IBS patient and 80 controls were recruited. All participants were asked to fill in a questionnaire included demographic information and medical history and also a stress questionnaire. Serum leptin level was measured by enzyme-linked immunosorbent assay method. Chi-square, Student t test, Pearson correlation and logistic regression were used for investigating the relationships between variables. RESULTS: Mean serum leptin levels were 7.41 and 19.33 ng/mL in IBS and control groups, respectively (P<0.001). Participants in IBS group had significantly higher stress levels than controls (P<0.001). Multivariate logistic regression analysis showed that adjusted odds ratios (ORs) for serum leptin level (OR: 0.9; 95% confidence interval: 0.85-0.94) and stress level (OR: 1.15; 95% confidence interval: 1.09-1.23) were nearly the same as crude ones. CONCLUSIONS: This study indicated the relationship between leptin and IBS for the first time. Our results show that serum leptin level is significantly lower in IBS group than controls and this relationship is independent of other variables such as stress levels, body mass index, etc. This may help in better understanding of the pathogenesis of IBS and consequently lead to the development of more effective treatments. © 2009 Lippincott Williams & Wilkins, Inc.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Clin. Gastroenterol. [Field not mapped to EPrints] C2 - 19398923 [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Faculty of Para-medicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Clinical Research Center, 5th Azar Hospital, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Irritable bowel syndrome, Leptin, Stress, leptin, adult, article, body mass, case control study, controlled study, demography, disease association, enzyme linked immunosorbent assay, female, hormone blood level, human, hypothesis, irritable colon, major clinical study, male, pathogenesis, pathophysiology, priority journal, questionnaire, stress, Adult, Biological Markers, Case-Control Studies, Chi-Square Distribution, Down-Regulation, Enzyme-Linked Immunosorbent Assay, Female, Humans, Irritable Bowel Syndrome, Leptin, Logistic Models, Male, Middle Aged, Odds Ratio, Risk Assessment, Risk Factors, Stress, Psychological, Young Adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 08:50
Last Modified: 17 Mar 2018 09:43
URI: http://eprints.goums.ac.ir/id/eprint/2255

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