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Sentinel hospital-based surveillance of Rotavirus diarrhea in Iran

Eesteghamati, A. and Gouya, M. and Keshtkar, A. and Najafi, L. and Zali, M.R. and Sanaei, M. and Yaghini, F. and El Mohamady, H. and Patel, M. and Klena, J.D. and Teleb, N. (2009) Sentinel hospital-based surveillance of Rotavirus diarrhea in Iran. Journal of Infectious Diseases, 200 (SUPPL.). S244-S247. ISSN 00221899 (ISSN)

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Abstract

Background. Rotavirus is the most common causes of severe, acute diarrhea during childhood and is an important cause of morbidity and mortality in developing countries. We established active hospital-based surveillance of childhood diarrhea to assess the scope of severe rotavirus disease in Iran. Methods. From May 2006 through April 2007, prospective surveillance of rotavirus diarrhea among children aged <5 years was conducted in 5 sentinel hospitals in Iran. Stool samples were tested for rotavirus using a commercially available enzyme immunoassay, and rotavirus-positive samples were genotyped using reverse-transcriptase polymerase chain reaction. Results. Of 2198 children admitted to the hospital for acute gastroenteritis, 1298 (59.1%) had stool samples test positive for rotavirus by enzyme immunoassay. Of the rotavirus episodes, 85% occurred during the first 2 years of life, with the peak prevalence of severe rotavirus disease occurring from September through January. Among the 110 rotavirus-positive samples that were genotyped, G4P[8] was the most commonly detected rotavirus genotype (30.9% of strains). Other commonly detected genotypes included P[8] with G nontypeable (21.8%), G4 with P nontypeable (13.6%), G1[P8] (10.9%), and G2[P4] (5.5%). Conclusions. Rotavirus is the most common cause of severe diarrhea in Iran, which indicates that safe and effective rotavirus vaccination in Iran is a public health priority. © 2009 by the Infectious Diseases Society of America. All rights reserved.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Infect. Dis. [Field not mapped to EPrints] C2 - 19821714 [Field not mapped to EPrints] AD - Center of Disease Control and Prevention, Ministry of Health and Medical Education, Tehran, Iran [Field not mapped to EPrints] AD - Research Center of Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Department of Preventive Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Naval Medical Research Unit 3, Cairo, Egypt [Field not mapped to EPrints] AD - Regional Office for the Eastern Mediterranean, World Health Organization, Cairo, Egypt [Field not mapped to EPrints] AD - Centers for Disease Control and Prevention, Atlanta GA, United States [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: acute gastroenteritis, article, child, disease severity, enzyme immunoassay, feces analysis, genotype, health survey, human, infant, infectious diarrhea, Iran, major clinical study, preschool child, prevalence, priority journal, prospective study, reverse transcription polymerase chain reaction, Rotavirus, virus detection, virus typing, Child, Preschool, Cost of Illness, Diarrhea, Hospitalization, Humans, Infant, Infant, Newborn, Iran, Rotavirus, Rotavirus Infections
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 04:05
Last Modified: 27 Feb 2017 07:02
URI: http://eprints.goums.ac.ir/id/eprint/2252

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