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Genetic polymorphisms of glutathione S-transferase genes GSTP1, GSTM1, and GSTT1 and risk of esophageal and gastric cardia cancers

Zendehdel, K. and Bahmanyar, S. and McCarthy, S. and Nyren, O. and Andersson, B. and Ye, W. (2009) Genetic polymorphisms of glutathione S-transferase genes GSTP1, GSTM1, and GSTT1 and risk of esophageal and gastric cardia cancers. Cancer Causes and Control, 20 (10). pp. 2031-2038. ISSN 09575243 (ISSN)

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Abstract

Glutathione S-transferase (GST) enzymes are known to metabolize tobacco-related carcinogens. Previous studies on the association of functional polymorphisms of GST genes with esophageal squamous cell carcinoma have yielded conflicting but overall null results. A few studies of esophageal adenocarcinoma were likewise conflicting, but the scarcity of data is striking. We aimed to study associations of the GSTM1 and GSTT1 null deletion polymorphisms as well as the GSTP1 Ile105Val polymorphism with risks for esophageal and gastric cardia cancers. DNA was prepared from 96 and 79 cases of esophageal adenocarcinoma and squamous cell carcinoma, respectively, 126 cardia cancer cases, and 471 population-based controls. Pyrosequencing typed the GSTP1 Ile105Val polymorphism, while multiplex PCR detected GSTM1 and GSTT1 deletions. Logistic regression modeling estimated odds ratios (ORs) with 95% confidence intervals (CIs). None of the studied polymorphisms were related to the risk of esophageal adenocarcinoma, but the variant GSTP1 Val 105 allele was associated with an increased risk of esophageal squamous cell carcinoma (OR = 1.7; 95% CI 1.0-2.9) and tended to be weakly, positively linked to cardia cancer (OR = 1.4; 95% CI 0.9-2.1). Finally, we performed a meta-analysis and found that GSTP1 polymorphism seems to be associated with the risk of esophageal squamous cell carcinoma among Caucasian population (OR = 1.4; 95% CI 1.0-2.2; p value for heterogeneity test 0.34). © 2009 Springer Science+Business Media B.V.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Cancer Causes Control [Field not mapped to EPrints] C2 - 19618282 [Field not mapped to EPrints] AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, Stockholm 171 77, Sweden [Field not mapped to EPrints] AD - Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden [Field not mapped to EPrints] AD - Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Esophageal cancer, Gastric cardia cancer, Glutathione S-transferase, GSTM1, GSTP1, GSTT1, Risks, DNA, glutathione transferase M1, glutathione transferase P1, glutathione transferase T1, isoleucine, valine, adult, aged, allele, article, cancer risk, cardia carcinoma, Caucasian, controlled study, esophageal adenocarcinoma, esophageal squamous cell carcinoma, female, genetic association, genetic heterogeneity, genetic polymorphism, genetic variability, human, major clinical study, male, multiplex polymerase chain reaction, null allele, population research, priority journal, pyrosequencing, Adenocarcinoma, Aged, Carcinoma, Squamous Cell, Cardia, Esophageal Neoplasms, Female, Genetic Predisposition to Disease, Glutathione S-Transferase pi, Glutathione Transferase, Humans, Male, Middle Aged, Polymorphism, Genetic, Risk Factors, Stomach Neoplasms
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 10:14
Last Modified: 01 Mar 2017 06:48
URI: http://eprints.goums.ac.ir/id/eprint/2251

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