Golestan University of Medical Sciences Repository

Gene polymorphism in transforming growth factor-beta codon 10 is associated with susceptibility to Giardiasis

Taherkhani, H. and Hajilooi, M. and Fallah, M. and Khyabanchi, O. and Haidari, M. (2009) Gene polymorphism in transforming growth factor-beta codon 10 is associated with susceptibility to Giardiasis. International Journal of Immunogenetics, 36 (6). pp. 345-349. ISSN 17443121 (ISSN)

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Abstract

Secretory immunoglobulin A (S-IgA) antibodies have a central role in anti-Giardial defence. It has been demonstrated that transforming growth factor-beta1 (TGF-P1) stimulates B lymphocytes to produce and secrete S-IgA. We sought to determine the association between TGF-β1 polymorphism (T+869C) with susceptibility to Giardiasis. The TGF-β1 genotypes and levels of salivary (S-IgA) were analysed in individuals with Giardiasis (97 symptomatic and 57 asymptomatic) and controls (n = 92). Individuals with symptomatic Giar- diasis had the lowest levels of S-IgA compared to individuals in asymptomatic Giardiasis and control groups (97%, 73% and 43%, <1 g L-1, respectively, P = 0.002). The frequency of allele C and CC genotypes of TGF-β1 polymorphism was significantly higher among symptomatic patients than asymptomatic and control groups. Logistic regression analysis demonstrated that the individuals homozygous for allele C of TGF-β1 had a significantly higher risk for symptomatic Giardiasis with odds ratio of 2.76 (95% CI: 3.88, 1.71, P = 0.007). Among the participants with TT genotype per cent of individuals with S-IgA level of more than 1gL″1 was almost twice the percentage in CC genotype individuals (14% versus 7% respectively P = 0.01). Our data suggest that CC genotype of TGF-β1 polymorphism at codon 10 is associated with occurrence of Giardiasis. ©2009 Blackwell Publishing Ltd.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Int. J. Immunogenet. [Field not mapped to EPrints] C2 - 19703231 [Field not mapped to EPrints] AD - Medical Parasitology Department, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Immunology Department, Hamadan University of Medical Sciences, Hamadan, Iran [Field not mapped to EPrints] AD - Medical Parasitology Department, University of Medical Sciences, Hamadan, Iran [Field not mapped to EPrints] AD - Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX, United States [Field not mapped to EPrints] AD - Atherosclerosis Research Laboratory, Texas Heart Institute, 6770 Bertner Ave, Houston, TX 77030, United States [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: secretory immunoglobulin, transforming growth factor beta1, immunoglobulin A, transforming growth factor beta1, article, codon, controlled study, DNA polymorphism, female, gene frequency, genetic susceptibility, genotype, giardiasis, homozygosity, human, Iran, major clinical study, male, priority journal, saliva level, allele, genetic polymorphism, genetic predisposition, genetics, giardiasis, homozygote, immunology, metabolism, regression analysis, risk, saliva, Alleles, Codon, Female, Genetic Predisposition to Disease, Genotype, Giardiasis, Homozygote, Humans, Immunoglobulin A, Male, Odds Ratio, Polymorphism, Genetic, Regression Analysis, Saliva, Transforming Growth Factor beta1
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 05:15
Last Modified: 01 Mar 2017 10:07
URI: http://eprints.goums.ac.ir/id/eprint/2245

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