Golestan University of Medical Sciences Repository

Effect of Urtica dioica L extract on quantitative morphometric alterations of liver parenchymal cells in STZ diabetic rats

Golalipour, M.J. and Ghafari, S. and Farsi, M.M. (2009) Effect of Urtica dioica L extract on quantitative morphometric alterations of liver parenchymal cells in STZ diabetic rats. International Journal of Morphology, 27 (4). pp. 1339-1344. ISSN 07179367 (ISSN)

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Abstract

Diabetes is associated with several structural and functional liver abnormalities that affect glycogen and lipid metabolism. In this study, an attempt was made to evaluate the effects of hydroalcoholic extract of Urtica dioica leaves on Quantitative morphometric changes in parenchymal cells of the livers in STZ diabetic rats. Thirty male Wistar rats were allocated in 3 groups: normal, diabetic and treatment. Hyperglycemia was induced by 80 mg/kg Streptozotocin intraperitoneally. One week after the injection of STZ, the third group received the hydroalcoholic extract of Urtica dioica at 100 mg/kg/day over four weeks. After five weeks, the animals were sacrificed and whole livers were removed. Liver specimens were used for quantitative morphometric analyze after hematoxylin and eosin staining. All data are shown as means plus standard errors of means and were analyzed using One-Way ANOVA test at P<0.05.The mean area of hepatocytes, nuclei and nucleolus had a decrease in periportal zone and an increase in perivenous zone in the diabetic and treatment groups. The increase of hepatocyte area in perivenous zone and reduce of nucleus area in periportal zone was significant in the diabetic group in comparison with control group (P<0.05), but were not significant between treatment and diabetic group. This study showed that administration of 100 mg/kg/day of Urtica dioica leaves extracts after induction of diabetes can cause a little modulating in the main morphometric indices of liver such as area of hepatocytes, nuclei and nucleolus in periportal and perivenous zones.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - Spanish [Field not mapped to EPrints] ST - Efecto del extracto de Urtica dioica sobre alteraciones morfométricas cuantitativas de las células del parénquima hepático en ratas STZ diabéticas [Field not mapped to EPrints] J2 - Int. J. Morphol. [Field not mapped to EPrints] AD - Department of Anatomical Sciences (Histology and Embryology), Gorgan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Anatomy, Babol University of Medical Sciences, Babol, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Diabetes, Hepatocyte, Liver, Morphometry, Urtica dioica
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 08:52
Last Modified: 01 Mar 2017 09:22
URI: http://eprints.goums.ac.ir/id/eprint/2243

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