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Serum lipid peroxidation and leptin levels in male and female type 2 diabetic patients in Gorgan (south east of Caspian Sea), Iran

Marjani, A. and Veghari, G. and Badeleh, M.T. (2009) Serum lipid peroxidation and leptin levels in male and female type 2 diabetic patients in Gorgan (south east of Caspian Sea), Iran. Journal of Clinical and Diagnostic Research, 3 (6). pp. 1903-1910. ISSN 0973709X (ISSN)

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Abstract

Background: The aim of the present study was to determinate the possible relationship between serum leptin and lipid peroxidation in male and female type 2 diabetic patients in Gorgan, Iran. Methods: The subjects consisted of fifty type 2 diabetic patients and fifty age and sex-matched control subjects. The concentration of leptin, malondialdehyde, lipid parameters and insulin were measured in all subjects. The results were evaluated by using Independent sample 't' test and Spearman's correlation coefficient test. Results: Leptin was correlated with BMI (male: r=0.339 and female: r=0.426, p<0.05) and malondialdehyde levels (male: r=0.124 and female: r=0.271, p<0.05) in the type-2 diabetic patients. In the control subjects, only a correlation between leptin and BMI was found (male: r=0.165, female: r= 0.037, p<0.05). Conclusions: In the correlation analysis using leptin as the dependent variable, BMI was found to be the predictor of leptin in males and females. Increased lipid peroxidation and hyperleptinaemia may play a role in the beginning and development of type 2 diabetes mellitus in this area.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Clin. Diagn. Res. [Field not mapped to EPrints] AD - Department of Biochemistry and Biophysics, Biochemistry and Metabolic Disorder Research Center, Golestan University of Medical Sciences, Gorgan, Golestan province, Iran [Field not mapped to EPrints] AD - Department of Anesthesia, Golestan University of Medical Sciences, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Gorgan, Leptin, Lipid peroxidation, Type 2 diabetes mellitus, glucose, high density lipoprotein cholesterol, insulin, leptin, lipid, low density lipoprotein cholesterol, malonaldehyde, triacylglycerol, very low density lipoprotein cholesterol, adult, article, blood sampling, body mass, cholesterol blood level, clinical article, clinical evaluation, concentration (parameters), controlled study, correlation analysis, correlation coefficient, enzyme linked immunosorbent assay, female, glucose blood level, hormone blood level, human, hyperleptinemia, insulin blood level, lipid blood level, lipid peroxidation, male, non insulin dependent diabetes mellitus, oxidative stress, Student t test, triacylglycerol blood level
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 08:06
Last Modified: 04 Mar 2017 10:16
URI: http://eprints.goums.ac.ir/id/eprint/2237

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