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Cancer risk among patients with cystic fibrosis and their first-degree relatives

Johannesson, M. and Askling, J. and Montgomery, S.M. and Ekbom, A. and Bahmanyar, S. (2009) Cancer risk among patients with cystic fibrosis and their first-degree relatives. International Journal of Cancer, 125 (12). pp. 2953-2956. ISSN 00207136 (ISSN)

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Abstract

Patients with cystic fibrosis (CF) are at increased risk of some cancers. Little is known about the cancer risks among carriers heterozygous for the CF mutation and it is hypothesized this may be associated with reduced cancer risk. Using Swedish general population-based registers, we identified 884 patients with CF from 1968 to 2003 and 3,033 of their first-degree relatives The subjects were followed from birth of index persons or 1958, whichever came later, until death, emigration or 2003, whichever came first. Cancer risks were compared with the general Swedish population using standardized incidence ratios (SIR) with 95% confidence intervals (CI). Patients, followed for an average of 21 years, were at a higher overall risk of cancer. Some 26 cancer diagnoses, after excluding multiple diagnoses of nonmelanoma skin cancer in one man, produced an overall SIR of 3.2 (95%CI 2.1-4.6).We found statistically significantly increased risks for kidney, thyroid, endocrine, lymphoma and nonmelanoma skin cancer. There was no modification of cancer risk among parents and siblings, with an average of 21 years of follow-up. This study did not identify a heterozygote advantage for CF gene mutations in relation to cancer risk. © 2009 UICC.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Int. J. Cancer [Field not mapped to EPrints] C2 - 19551859 [Field not mapped to EPrints] AD - Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology Section, Uppsala University, Uppsala, Sweden [Field not mapped to EPrints] AD - School of Health and Medical Sciences, Örebro University, University Hospital, Örebro, Sweden [Field not mapped to EPrints] AD - Department of Medicine, Karolinska Institutet, Karolinska Hospital, SE-171 76 Stockholm, Sweden [Field not mapped to EPrints] AD - Clinical Research Centre, Örebro University Hospital, Örebro, Sweden [Field not mapped to EPrints] AD - Department of Primary Care and Social Medicine, Charing Cross Hospital, Imperial College, London, United Kingdom [Field not mapped to EPrints] AD - Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Cancer, Cystic fibrosis, Gene mutation, Risk, adult, article, brain cancer, breast cancer, cancer risk, controlled study, cystic fibrosis, digestive system cancer, endocrine tumor, female, follow up, gene mutation, gynecologic cancer, heterozygote, human, kidney cancer, lymphoma, major clinical study, male, male genital tract cancer, melanoma, parent, priority journal, relative, respiratory tract cancer, risk assessment, sibling, skin cancer, Sweden, thyroid cancer, urinary tract cancer, Adult, Aged, Cohort Studies, Cystic Fibrosis, Family, Fathers, Female, Follow-Up Studies, Genetic Predisposition to Disease, Heterozygote, Humans, Male, Middle Aged, Mothers, Neoplasms, Risk Factors, Siblings, Sweden, Young Adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 05:08
Last Modified: 01 Mar 2017 06:07
URI: http://eprints.goums.ac.ir/id/eprint/2235

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