Golestan University of Medical Sciences Repository

Prevalence of esophageal cancer risk factors among Turkmen and non-Turkmen ethnic groups in a high incidence area in Iran

Marjani, H.A. and Biramijamal, F. and Hossein-Nezhad, A. and Islami, F. and Pourshmas, A. and Semnan, S. (2010) Prevalence of esophageal cancer risk factors among Turkmen and non-Turkmen ethnic groups in a high incidence area in Iran. Archives of Iranian Medicine, 13 (2). pp. 111-115. ISSN 10292977 (ISSN)

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Background: Golestan Province in north-eastern Iran has one of the highest incidence rates for esophageal squamous cell carcinoma (ESCC) worldwide. Earlier studies have reported higher incidence rates in the areas of Golestan which are mainly inhabited by individuals of the Turkmen ethnic group. However, it is not clear whether in those areas the incidence among Turkmens is higher in comparison to non-Turkmens. Some previous studies have suggested that environmental factors might play a more essential role in ESCC carcinogenesis in Golestan than a genetic background. If environmental factors instead of a genetic background are the major risk factors, therefore the prevalence of known environmental risk factors would not significantly differ among ESCC cases of different ethnic groups. To investigate the role of environmental factors versus genetic background by using the above concept, we have compared the prevalence of known risk factors for ESCC among Turkmen and non-Turkmen ESCC cases. Methods: Study participants were histopathologically proven ESCC cases from Golestan Province. They were recruited in the study from December 2003 to June 2007. The prevalence of the most important known risk factors for ESCC in Turkmen and non-Turkmen ESCC cases was compared using Chi-squared and Fisher's exact tests. Results: Of 300 ESCC cases recruited in the study, 171 (57.0%) and 129 (43.0%) cases were Turkmen and non-Turkmen, respectively. In the majority of the investigated risk factors which included tobacco, nass, and opium use, hot and extremely hot tea consumption, as well as decreased levels of education; there was no significant difference between Turkmen and nonTurkmen ESCC cases in the prevalence of exposure. Conclusion: Our findings support the suggestion that a substantial difference between Turkmens and non-Turkmens in terms of genetic susceptibility to ESCC is unlikely. Nevertheless, the moderate effect of genetic factors cannot be ruled out. Further studies to investigate potential environmental and genetic risk factors of ESCC in Golestan and the interaction between environmental and genetic factors are warranted.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Arch. Iran. Med. [Field not mapped to EPrints] C2 - 20187664 [Field not mapped to EPrints] AD - National Institute of Genetic Engineering and Biotechnology (NIGEB), Iran [Field not mapped to EPrints] AD - Digestive Disease Research Center of Tehran University of Medical Sciences (DDRC), Tehran, Iran [Field not mapped to EPrints] AD - Research Center for Gastroenterology and Hepatology, Golestan University of Medical Sciences, Golestan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Esophageal squamous cell carcinoma (ESCC), Ethnicity, North-east Iran, opiate, adult, aged, article, cancer incidence, cancer risk, carcinogenesis, cigarette smoking, controlled study, educational status, environmental factor, esophagus cancer, ethnic group, female, fluid intake, genetic susceptibility, heredity, histopathology, human, Iran, major clinical study, male, opiate addiction, prevalence, risk factor, tea, urban rural difference, Aged, Alcohol Drinking, Educational Status, Esophageal Neoplasms, Ethnic Groups, Female, Humans, Incidence, Iran, Male, Middle Aged, Opioid-Related Disorders, Prevalence, Risk Factors, Smoking
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 09:01
Last Modified: 20 Jun 2015 03:47
URI: http://eprints.goums.ac.ir/id/eprint/2219

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