Azami, N.S. and Piri, M. and Oryan, S. and Jahanshahi, M. and Babapour, V. and Zarrindast, M.R. (2010) Involvement of dorsal hippocampal α-adrenergic receptors in the effect of scopolamine on memory retrieval in inhibitory avoidance task. Neurobiology of Learning and Memory, 93 (4). pp. 455-462. ISSN 10747427 (ISSN)
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Abstract
The present study evaluated the possible role of α-adrenergic receptors of the dorsal hippocampus on scopolamine-induced amnesia and scopolamine state-dependent memory in adult male Wistar rats. The animals were bilaterally implanted with chronic cannulae in the CA1 regions of the dorsal hippocampus, trained in a step-through type inhibitory avoidance task, and tested 24. h after training to measure step-through latency. Results indicate that post-training or pre-test intra-CA1 administration of scopolamine (1 and 2μg/rat) dose-dependently reduced the step-through latency, showing an amnestic response. Amnesia produced by post-training scopolamine (2μg/rat) was reversed by pre-test administration of the scopolamine that is due to a state-dependent effect. Interestingly, pre-test intra-CA1 microinjection of α1-adrenergic agonist, phenylephrine (1 and 2μg/rat) or α2-adrenergic agonist, clonidine improved post-training scopolamine (2μg/rat)-induced retrieval impairment. Furthermore, pre-test intra-CA1 microinjection of phenylephrine (0.25, 0.5 and 1 μg/rat) or clonidine (0.25, 0.5 and 1 μg/rat) with an ineffective dose of scopolamine (0.25 μg/rat), synergistically improved memory performance impaired by post-training scopolamine. On the other hand, pre-test injection of α1-receptors antagonist prazosin (1 and 2 μg/rat) or α2-receptors antagonist yohimbine (1 and 2 μg/rat) prevented the restoration of memory by pre-test scopolamine. It is important to note that pre-test intra-CA1 administration of the same doses of prazosin or yohimbine, alone did not affect memory retrieval. These results suggest that α1- and α2-adrenergic receptors of the dorsal hippocampal CA1 regions may play an important role in scopolamine-induced amnesia and scopolamine state-dependent memory. © 2010 Elsevier Inc.
| Item Type: | Article |
|---|---|
| Additional Information: | Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Neurobiol. Learn. Mem. [Field not mapped to EPrints] C2 - 20064624 [Field not mapped to EPrints] AD - Department of Biology, Sciences and Research Branch, Islamic Azad University, Tehran, Iran [Field not mapped to EPrints] AD - Department of Biology, Islamic Azad University, Ardabil branch, Ardabil, Iran [Field not mapped to EPrints] AD - Neuroscience Research Centre, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Institute for Cognitive Science Studies, Tehran, Iran [Field not mapped to EPrints] AD - School of Advanced Medical Technologies and Iranian National Center for Addiction Studies, Teheran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints] |
| Uncontrolled Keywords: | Clonidine, Dorsal hippocampus, Phenylephrine, Prazosin, Scopolamine, Yohimbine, alpha 1 adrenergic receptor, alpha 2 adrenergic receptor, clonidine, phenylephrine, scopolamine, amnesia, animal experiment, animal model, animal tissue, article, avoidance behavior, controlled study, hippocampus, latent period, male, memory consolidation, mental performance, nonhuman, protein function, rat, state dependent learning, Adrenergic alpha-Agonists, Adrenergic alpha-Antagonists, Animals, Avoidance Learning, CA1 Region, Hippocampal, Dose-Response Relationship, Drug, Hippocampus, Mental Recall, Neuropsychological Tests, Nootropic Agents, Rats, Rats, Wistar, Receptors, Adrenergic, alpha, Receptors, Adrenergic, alpha-1, Receptors, Adrenergic, alpha-2, Scopolamine, Time Factors |
| Subjects: | مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus موارد کلی |
| Divisions: | معاونت تحقیقات و فناوری |
| Depositing User: | GOUMS |
| Date Deposited: | 19 Apr 2015 05:45 |
| Last Modified: | 17 Mar 2018 09:31 |
| URI: | http://eprints.goums.ac.ir/id/eprint/2216 |
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