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Legg-Calve´-Perthes disease and risks for cardiovascular diseases and blood diseases

Hailer, Y.D. and Montgomery, S.M. and Ekbom, A. and Nilsson, O.S. and Bahmanyar, S. (2010) Legg-Calve´-Perthes disease and risks for cardiovascular diseases and blood diseases. Pediatrics, 125 (6). e1308-e1315. ISSN 00314005 (ISSN)

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OBJECTIVE: We hypothesized that patients with Legg-Calve´-Perthes disease (LCPD) might have higher risks of cardiovascular and blood diseases. METHODS: A total of 3141 patients, 2 to 15 years of age, with LCPD diagnosed between 1965 and 2005 were identified with the Swedish Inpatient Register. A total of 15 595 individuals without LCPD were selected randomly from among the Swedish general population, with matching according to year of birth, age, gender, and region of residence. Cox proportional-hazard regression analyses, with adjustment for socioeconomic index, were used to estimate relative risks. The patients also were compared with their same-gender siblings. RESULTS: Patients with LCPD had a hazard ratio (HR) of 1.70 (95% confidence interval [CI]: 1.39-2.09) for cardiovascular diseases, compared with individuals without LCPD. The point estimate was slightly higher among subjects >30 years of age at the follow-up (HR: 2.10 [95% CI: 1.52-2.91]). There were statistically significantly higher risks for blood diseases, including anemias and coagulation defects (HR: 1.41 [95% CI: 1.07-1.86]), which were more pronounced among subjects >30 years of age at the follow-up (HR: 2.70 [95% CI: 1.50-4.84]). Patients also had statistically significantly higher risks of hypertensive disease (HR: 2.97 [95% CI: 1.87-4.72]) and nutritional anemia (HR: 2.92 [95% CI: 1.58-5.40]). Analyses using siblings as the comparison group showed consistent results for cardiovascular diseases. CONCLUSION: The results are consistent with the hypothesis that an insufficient blood supply to the femoral head, attributable to vascular pathologic conditions, is involved in the pathogenesis of LCPD. Copyright © 2010 by the American Academy of Pediatrics.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Pediatrics [Field not mapped to EPrints] C2 - 20439602 [Field not mapped to EPrints] AD - Uppsala University Hospital, Department of Orthopaedics, SE-75185 Uppsala, Sweden [Field not mapped to EPrints] AD - Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden [Field not mapped to EPrints] AD - Clinical Research Centre, Örebro University Hospital, Örebro, Sweden [Field not mapped to EPrints] AD - Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Coagulation, Hypertension, Ischemic heart disease, Legg-Calve´-Perthes disease, Risk factors, adolescent, anemia, article, blood clotting disorder, blood disease, cardiovascular disease, cardiovascular risk, child, clinical assessment, controlled study, cor pulmonale, disease association, female, femur head, follow up, hemolytic anemia, human, hypertension, hypothesis, major clinical study, male, nutritional anemia, pathogenesis, Perthes disease, priority journal, proportional hazards model, risk assessment, sibling, socioeconomics, vascularization, blood flow, cardiovascular disease, femur, heart muscle ischemia, hematologic disease, hypertension, pathophysiology, Perthes disease, preschool child, Adolescent, Cardiovascular Diseases, Child, Child, Preschool, Female, Femur, Hematologic Diseases, Humans, Hypertension, Legg-Perthes Disease, Male, Myocardial Ischemia, Proportional Hazards Models, Regional Blood Flow, Socioeconomic Factors
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 03:42
Last Modified: 17 Mar 2018 09:29
URI: http://eprints.goums.ac.ir/id/eprint/2213

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