Golestan University of Medical Sciences Repository

Serum hyaluronic acid and laminin as biomarkers in liver fibrosis

Parsian, H. and Rahimipour, A. and Nouri, M. and Somi, M.H. and Qujeq, D. and Fard, M.K. and Agcheli, K. (2010) Serum hyaluronic acid and laminin as biomarkers in liver fibrosis. Journal of Gastrointestinal and Liver Diseases, 19 (2). pp. 169-174. ISSN 18418724 (ISSN)

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Abstract

Background and Aim: Non-invasive methods have been proposed as surrogate markers for liver biopsy. It was shown that serum hyaluronic acid (HA) and laminin (LN) levels increase with the development of liver fibrosis. The aim of this study was to determine serum HA and LN levels cut-off points for predicting liver fibrosis, highlighting their diagnostic value and their changes during treatment. Methods: Serum HA and LN levels in chronic hepatitis patients (n=62) and controls (n=20) were assessed by ELISA and liver histopathological parameters were evaluated by the modified Knodell score. Results: Mean serum HA (113.4±59.2 ng/ml) and LN (91.9±20.9 ng/ml) concentrations in patients were greater than in controls (46.6±10.5 and 46.1±10.1 ng/ml, p<0.001). A strong correlation between serum HA and LN concentrations with hepatic necroinflammatory lesions was found (p<0.001). A cut-off point of 59.5 ng/ml HA and 52.0 ng/ml LN for the discrimination of patients with liver fibrosis from healthy controls and 102.0 ng/ml HA and 92.5 ng/ml LN for the discrimination of patients with mild from severe fibrosis showed acceptable AUC, sensitivity and specificity. After six months of treatment, a gradual decrease in serum HA and LN levels was observed, however the levels were still higher than those of the controls (p<0.05). Conclusions: Serum hyaluronic acid and laminin concentrations increase in liver fibrosis and could be used as a noninvasive biomarker to discriminate between patients with liver fibrosis and healthy individuals.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Gastrointest. Liver Dis. [Field not mapped to EPrints] C2 - 20593050 [Field not mapped to EPrints] AD - Department of Biochemistry and Biophysics, Babol University of Medical Sciences, Babol, Iran [Field not mapped to EPrints] AD - Department of Clinical Biochemistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Liver and Gastrointestinal Diseases Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran [Field not mapped to EPrints] AD - Yahya Nezhad Hospital, Babol University of Medical Sciences, Babol, Iran [Field not mapped to EPrints] AD - Liver and Gastrointestinal Diseases Research Centre, Gorgan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Chronic hepatitis, Hepatic fibrosis, Hyaluronic acid, Knodell score, Serum laminin, biological marker, hyaluronic acid, laminin, adolescent, adult, aged, article, chronic hepatitis, controlled study, diagnostic accuracy, diagnostic test, diagnostic value, disease course, enzyme linked immunosorbent assay, female, histopathology, human, human tissue, Knodell score, laboratory test, liver disease, liver fibrosis, major clinical study, male, prediction, scoring system, serum, virus hepatitis, Adolescent, Adult, Aged, Anti-Inflammatory Agents, Antiviral Agents, Biological Markers, Biopsy, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Female, Hepatitis B, Chronic, Hepatitis C, Chronic, Hepatitis, Autoimmune, Humans, Hyaluronic Acid, Iran, Laminin, Liver, Liver Cirrhosis, Male, Middle Aged, Predictive Value of Tests, Severity of Illness Index, Time Factors, Treatment Outcome, Up-Regulation, Young Adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 09:30
Last Modified: 20 Jun 2015 08:25
URI: http://eprints.goums.ac.ir/id/eprint/2210

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