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Maternal Folate and vitamin B12 status and neural tube defects in:Northern Iran A case control study

Mobasheri, E. and Keshtkar, A. and Golalipour, M.-J. (2010) Maternal Folate and vitamin B12 status and neural tube defects in:Northern Iran A case control study. Iranian Journal of Pediatrics, 20 (2). pp. 167-173. ISSN 10184406 (ISSN)

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Abstract

Objective: This study was conducted to determine the serum level of folic acid and vitamin B12 in neural tube defects pregnancies (NTD) and healthy controls in Northern Iran. Methods: This case-control study was performed on women with neural tube defects pregnancies and controls with unaffected pregnancies in Northern Iran during 2006. Twenty three pregnant women whose pregnancies were diagnosed as NTD by a second-trimester ultrasonographic examination were recruited as cases. The control group (n=23) consisted of women who were selected among socio-economic status (SES) matched women who had a normal targeted ultrasound during the second trimester with documented normal fet al outcome. Fetal NTD was suspected with targeted second-trimester ultrasound during the 16th week of gestation and confirmed with high maternal serum α-fetoprotein levels. Folate, vitamin B12, homocysteine and alpha fetoprotein were evaluated after target ultrasonography. Findings: Serum alpha fetoprotein level (mean ± SD) in cases and controls was 120.2±64.1 and 50±33.5 iu/ml, respectively (P<0.05). The mean ± SD folate in cases and controls was 8.4±4.2 versus 9.3±4.2 ng/ml, respectively. This difference was not significant. Folate deficiency was found in 30.4% of the cases and 13% of the controls (OR = 2.9, 95%: 0.54-19.8). Vitamin B12 deficiency was found in 13 % of cases and 17.7% of the controls (OR=0.7, 95%: 0.1-4.9). Conclusion: This study showed that the probability of having a newborn with NTDs in maternal folate deficiency is three times higher than with normal folate in Northern Iran. © 2010 by Pediatrics Center of Excellence.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Iran. J. Pediatr. [Field not mapped to EPrints] AD - Department of Gynecology, Gorgan Congenital Malformations Research Center, Gorgan University of Medical Sciences, Gorgan, IR, Iran [Field not mapped to EPrints] AD - Department of Social Medicine, Gorgan University of Medical Sciences, Gorgan, IR, Iran [Field not mapped to EPrints] AD - Department of Embryology, Gorgan Congenital Malformations Research Center, Gorgan University of Medical Sciences, P.O. Box: 49175-553, Gorgan, IR, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Folic acid deficiency, Iran, Neural tube defects, Pregnancy, Vitamin B12, alpha fetoprotein, cyanocobalamin, folic acid, homocysteine, adult, article, clinical article, controlled study, cyanocobalamin deficiency, female, fetus echography, folic acid blood level, folic acid deficiency, gestational age, hospital based case control study, human, Iran, maternal nutrition, neural tube defect, prenatal diagnosis, protein blood level, second trimester pregnancy, social status, vitamin blood level
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 06:46
Last Modified: 17 Jan 2017 10:25
URI: http://eprints.goums.ac.ir/id/eprint/2207

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