Golestan University of Medical Sciences Repository

Gender-specific differences in the association of adiponectin gene polymorphisms with body mass index

Tabatabaei-Malazy, O. and Hasani-Ranjbar, S. and Amoli, M.M. and Heshmat, R. and Sajadi, M. and Derakhshan, R. and Amiri, P. and Namakchian, M. and Rezazadeh, E. and Tavakkoly-Bazzaz, J. and Keshtkar, A. and Larijani, B. (2010) Gender-specific differences in the association of adiponectin gene polymorphisms with body mass index. Review of Diabetic Studies, 7 (3). pp. 249-254. ISSN 16136071 (ISSN)

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Abstract

OBJECTIVE: Adiponectin gene polymorphisms are associated with obesity, metabolic syndrome and type 2 diabetes (T2D). The study evaluated possible associations of +45T/G and -11391G/A adiponectin gene polymorphisms with body mass index (BMI), waist circumferences (WC), and blood pressure in diabetic and non-diabetic Iranians. METHODS: This cross-sectional study involved two groups of subjects: 243 diabetic patients and 173 non-diabetic subjects recruited from Rafsanjan city in the south-east of Iran. RESULTS: No significant association was found between +45T/G and - 11391G/A adiponectin gene polymorphisms and systolic or diastolic blood pressure. However, male carriers of the TT genotype of +45T/G had a significantly higher mean BMI than male GG homozygotes (p = 0.018). Also, male carriers of the GG genotype of -11391G/A had significantly higher mean BMI than male GA or AA homozygotes (p = 0.041). Female carriers of the GG genotype of -11391G/A had significantly higher mean WC than female GA or AA homozygotes (p = 0.038). CONCLUSIONS: We observed a significantly higher BMI in women, and GA or AA carriers of - 11391G/A polymorphism. Also, there was a significantly lower WC in females and GG carriers of +45T/G. These results point to a gender-specific impact of the studied genotypes on BMI and WC.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Rev. Diabetic Stud. [Field not mapped to EPrints] AD - Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran [Field not mapped to EPrints] AD - Division Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Adiponectin, Blood pressure, BMI, Body mass index, Gender, Metabolic syndrome, Polymerase chain reaction, Polymorphism, Type 2 diabetes, Waist, adiponectin, article, blood pressure, body mass, cross-sectional study, diabetic patient, diastolic blood pressure, female, gene frequency, genetic association, genotype, heterozygote, human, Iran, major clinical study, male, non insulin dependent diabetes mellitus, sex difference, single nucleotide polymorphism, systolic blood pressure, waist circumference
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 04:35
Last Modified: 20 Jun 2015 06:01
URI: http://eprints.goums.ac.ir/id/eprint/2187

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