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High frequency of the IL-2 -330 T/HLA-DRB1*1501 haplotype in patients with multiple sclerosis

Shahbazi, M. and Roshandel, D. and Ebadi, H. and Fathi, D. and Zamani, M. and Boghaee, M. and Mohammadhoseeeni, M. and Rshaidbaghan, A. and Bakhshandeh, A. and Shahbazi, S. (2010) High frequency of the IL-2 -330 T/HLA-DRB1*1501 haplotype in patients with multiple sclerosis. Clinical Immunology, 137 (1). pp. 134-138. ISSN 15216616 (ISSN)

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Abstract

We have evaluated the role of the HLA-DRB1*1501 allele and the IL-2 -330 T/G polymorphism and their interaction in susceptibility to multiple sclerosis on 360 patients and 426 matched healthy individuals. We used the SSP-PCR method to determine the alleles. Fisher's exact test was used to analyses. We observed a significant increase in the T allele at IL-2 -330 position in patients (OR = 1.34, P<0.05), and the T/T and T/G genotypes were more frequent among patients than controls. The HLA-DRB1*1501 allele was overrepresented in patients as compared to the control group (OR = 1.7, P=0.0006). The two-locus analysis of the interaction between the IL-2 promoter polymorphism and the HLA-DRB1 allele showed that the HLA-DRB1*1501/T haplotype was more frequent in patients than controls (OR=16, P<0.0001). Our findings support previous findings about the role of the HLA-DRB1*1501 allele in susceptibility to MS. This work also provides new findings about the importance of gene-gene interactions in the development of MS. © 2010 Elsevier Inc.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Clin. Immunol. [Field not mapped to EPrints] C2 - 20594918 [Field not mapped to EPrints] AD - Medical Cellular and Molecular Research Center, Talghani Children Hospital of Golestan University of Medical Sciences, Bolv Janbazan, 4916668197, Gorgan, Iran [Field not mapped to EPrints] AD - Department of neurology, Medical Cellular and Molecular Research Center, 5Azar hospital of Golestan University of Medical Sciences, Bolv 5Azar, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Neurology, Iranian Center of Neurological Research, Imam Khomeini Hospital, Tehran University of Medical Sciences, Keshavarz Bolv, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Genetic susceptibility, HLA-DRB1*1501, Interleukin 2, Multiple sclerosis, Polymorphism, Predisposing factor, HLA DR antigen, interleukin 2, adult, allele, analysis, article, child, control group, controlled study, female, Fisher exact test, gene interaction, gene locus, genetic susceptibility, genotype, haplotype, human, major clinical study, male, multiple sclerosis, position, priority journal, promoter region, school child, single nucleotide polymorphism, Adult, Age of Onset, Female, Gene Frequency, Genotype, Haplotypes, HLA-DR Antigens, Humans, Interleukin-2, Iran, Male, Middle Aged, Multiple Sclerosis, Polymorphism, Single Nucleotide, Severity of Illness Index, Young Adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 03:34
Last Modified: 05 Apr 2017 10:05
URI: http://eprints.goums.ac.ir/id/eprint/2184

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