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Maternal and neonatal serum magnesium concentrations in neural tube defects pregnancies in Gorgan (North of Iran) - A case control study

Golalipour, M.J. and Mansourian, A.R. (2010) Maternal and neonatal serum magnesium concentrations in neural tube defects pregnancies in Gorgan (North of Iran) - A case control study. Journal of Clinical and Diagnostic Research, 4 (4). pp. 2817-2821. ISSN 0973709X (ISSN)

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Abstract

Objective: Neural tube defects (NTD) comprise a group of congenital malformations that include spinabifida, anencephaly and encephalocele. Previous studies have reported the embryotoxic and teratogenic effects of Magnesium deficiency in animal models. Therefore, this study was conducted to determine an association between Magnesium deficiency and neural tube defects in Northern Iran, which was reported to have a high prevalence of neural tube defects. Methods: This hospital based case control study was conducted on 13 mothers with newborns having neural tube defects and 35 healthy mothers as controls in Northern Iran during 2005-2006. Serum Magnesium was measured by spectrophotometery. Results: Serum Magnesium levels in mothers with NTD affected newborns and in mothers with healthy newborns were 1.5±0.6 and 1.32±0.3 micromol/litter, respectively. Overall, 46.2% mothers in the case group and 48.6 % mothers in the control group had Magnesium deficiency. Logistic regression analysis showed no association between the presence of NTD and Magnesium deficiency (OR =0.9, 95% Cl: 0.2-3.9, p=0.88). Serum Magnesium levels in newborns with NTD and healthy normal newborns were 1.4±0.6 micromol/litter and 1.3±0.4 micromol/litter, respectively. Overall, 30.8% newborns in the case group and 37.1 % newborns in the control group had Magnesium deficiency. Logistic regression analysis showed no association between the presence of NTD and Magnesium deficiency (OR =0.8, 95% Cl: 0.1-3.4 p=0.68). Conclusion: The present study did not find any association between the occurrence of NTD and Magnesium deficiency.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Clin. Diagn. Res. [Field not mapped to EPrints] AD - Department of Embryology, Gorgan Congenital Malformation Research Center, Gorgan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Biochemistry and metabolic disorder research center, Gorgan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Anencephaly, Iran, Magnesium deficiency, Neural tube defects, Spina bifida, magnesium, adult, article, birth weight, body height, case control study, clinical article, controlled study, disease association, female, gestational age, human, Iran, magnesium blood level, magnesium deficiency, neural tube defect, newborn, pregnancy, spectrophotometry, Animalia
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 08:12
Last Modified: 05 Apr 2017 10:10
URI: http://eprints.goums.ac.ir/id/eprint/2181

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