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Rate-dependent and antiarrhythmic reentrant tachycardia (AVNRT) effects of simvastatin in isolated rabbit atrioventricular nodal model

Khori, V. and Najafi, S.A. and Alizadeh, F. and Pourabouk, M. and Nayebpour, M. and Changizi, S. and Salehi, A. and Badaghabadi, F. and Alizadeh, A.M. (2010) Rate-dependent and antiarrhythmic reentrant tachycardia (AVNRT) effects of simvastatin in isolated rabbit atrioventricular nodal model. Journal of Mazandaran University of Medical Sciences, 20 (76). pp. 78-87. ISSN 17359279 (ISSN)

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Abstract

Background and purpose: Several previous studies have shown the direct and indirect effects of statins on supraventricular and ventricular arrhythmia. The purpose of the present study is to determine (1) whether Simvastatin modifies the rate-dependent properties of the AV node, (2) to what extent such changes are related to effect of Simvastatin on the basic properties of AV nodal conduction and refractoriness. Materials and methods: AV nodal refractoriness (AVERP & AVFRP) and rate dependency protocols Fatigue and Facilitation were used to assesse the electrophysiological properties of AV node. We used an isolated perfussed rabbit with AV nodal preparation in one group (N=8). The stimulation protocols were carried out during control phase and in the presence of various concentrations of Simvastatin (0.5 , 0.8 , 1, 3 ,10 μm). Results: Simvastatin in concentration-dependent manner successfully prolonged effective and functional nodal refractory period (AVERP & AVFRP). Also an increase in Wenckebach cycle length was observed. Simvastatin in high concentration (3,10 μm) increases the arrhythmia threshold. Various concentrations of simvastatin increased fatigue, but it reached to significant level only at 30 μM. Conclusion: Simvastatin has potential anti-AVNRT effects by elevating arrhythmia threshold and prolongation of nodal refractoriness.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - Persian [Field not mapped to EPrints] J2 - J. Mazandaran Univ. Med. Sci. [Field not mapped to EPrints] AD - Department of Pharmacology, Heart Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Heart Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Hakim Jorjani Hospital, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Heart, Heart Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Atrioventricular node, AVNRT, Simvastatin, hydroxymethylglutaryl coenzyme A reductase inhibitor, simvastatin, article, controlled study, drug mechanism, heart atrioventricular node, heart electrophysiology, heart supraventricular arrhythmia, heart ventricle arrhythmia, nonhuman, rabbit, Wenckebach period
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 04:37
Last Modified: 05 Apr 2017 10:18
URI: http://eprints.goums.ac.ir/id/eprint/2173

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