Golestan University of Medical Sciences Repository

Co-infection by hepatitis C virus in human immunodeficiency virus infected patients in southwest of Iran

Khosravi, A. and Bahmani, M. and Ghezel-Sofla, I. (2010) Co-infection by hepatitis C virus in human immunodeficiency virus infected patients in southwest of Iran. Iranian Journal of Clinical Infectious Diseases, 5 (4). pp. 223-227. ISSN 17355109 (ISSN)

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Background: Hepatitis C virus (HCV) has emerged as the cause of the second major epidemic of viral infection after human immunodeficiency virus (HIV) within the past two decades, and co-infection of HIV and HCV represents a growing problem for the future. The purpose of this study was to investigate the prevalence of HCV antibodies (anti-HCV) in patients with HIV in Fars province. Patients and methods: A total of 101 HIV-1-positive individuals (89 males, 12 females) from Fars province (Counseling Behavioral Modification Center in Shiraz) were included in the study. They were distributed according to risk factors for HIV infection as follows: 35(34.6%) IVDUs, 2(2%) sexual high-risk behavior, 50(49.5%) a combination of IVDUs and sexual behavior, 12(12%) from HIV positive partners and 2(2%) unknown. Detection of HCV antibodies was carried out by a third generation enzyme-linked immunosorbent assay. Results: Totally, 87 (84 males, 3 females) of 101 HIV-infected patients (86.1%) had antibodies to HCV. The prevalence of HCV antibodies was higher among the males (83.2%) than the females (3%). The prevalence of HCV antibodies was 94.4% in IVDUs, 96% in individuals with both IVDUs and sexual behavior risk factors and 25% in women who had HIV-positive partner. All unknown cases were positive for HCV and none of individuals who had sexual high-risk behavior were infected with HCV. Conclusion: The overall prevalence of HCV infection in HIV-positive individuals was 84.1%. The consistently high prevalence of HCV infection observed in HIV infected individuals supports the routine screening for HCV and continuous educational programs in these patients, especially among IVDUs in Iran. © 2010 IDTMRC, Infectious Diseases and Tropical Medicine Research Center.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Iran. J. Clin. Infect. Dis. [Field not mapped to EPrints] AD - Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - HIV and Hepatitis Research Center, Shiraz University of Medical Sciences, Gerash, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Hepatitis C virus (HCV), Human immunodeficiency virus (HIV), Intravenous drug user (IVDU), virus antibody, adult, antibody detection, antibody titer, article, controlled study, enzyme linked immunosorbent assay, female, hepatitis C, high risk behavior, human, Human immunodeficiency virus 1 infection, infection risk, intravenous drug abuse, Iran, major clinical study, male, mixed infection, risk assessment, risk factor, sex difference, sexual behavior
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 06:29
Last Modified: 20 Jun 2015 06:54
URI: http://eprints.goums.ac.ir/id/eprint/2167

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