Golestan University of Medical Sciences Repository

Radiation-induced lowered neurogenesis associated with shortened latency of inhibitory avoidance memory response

Jahanshahi, M. and Khoshnazar, A.K. and Azami, N.S. and Heidari, M. (2011) Radiation-induced lowered neurogenesis associated with shortened latency of inhibitory avoidance memory response. Folia Neuropathologica, 49 (2). pp. 103-108. ISSN 16414640 (ISSN)

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Abstract

The neural system is less sensitive to radiation than other late-responding organs and tissues such as the kidney and lung. The generation of new neurons in the adult mammalian brain has been documented in several works. Many studies show that adult hippocampal neurogenesis relates to hippocampal function, in several ways. In this study, we assessed the effect of single and fractionated cobalt radiation on neurogenesis in the dentate gyrus of the hippocampal formation. The irradiation time for delivering 2 Gy (for fractionated dose radiation) and 10 Gy (for single dose radiation) at maximum depth were respectively 1.98 min and 9.92 min. To study the association with memory function we examined inhibitory avoidance memory using a step-through device. Brains were withdrawn and fixed, and then sections were stained with cresyl violet for neurons. We found that a 10 Gy dose can induce lower neurogenesis in the dentate gyrus of the hippocampus (p < 0.05), in such a way that a fractionated dose (5 fractions of 2 Gy) is more effective than a single dose (one fraction of 10 Gy). Moreover, a fractionated dose could reduce step-through latency corresponding to damaged inhibitory avoidance memory (p < 0.05). Synergic action of an anaesthetic drug may be the cause of more reduction of neurogenesis in fractionated irradiated rats. There was no significant difference in latency of the inhibitory avoidance memory response between the single 10 Gy group and the sham group, while fractionated 10 Gy could reduce latency. Different mechanisms of action in the two regimens of irradiation may be a reason.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Folia Neuropathol. [Field not mapped to EPrints] AD - Department of Anatomy, Neuroscience Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Biochemistry and Medical Physics, Faculty of Medicine, Golestan University of Medical Sciences, km 4 Gorgan-Sari Road (Shastcola), Gorgan, Iran [Field not mapped to EPrints] AD - Department of Biology, Gorgan Branch, Islamic Azad University, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Cobalt radiation, Dentate gyrus, Inhibitory avoidance memory, Neurogenesis, Step-through, cobalt 60, ether, animal experiment, animal model, animal tissue, article, avoidance behavior, brain tissue, cobalt therapy, controlled study, dentate gyrus, drug mechanism, hippocampus, immunohistochemistry, latent period, male, medical instrumentation, memory, nervous system development, nonhuman, psychologic test, radiation depth dose, radiation dose fractionation, radiation response, rat
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 04:25
Last Modified: 23 May 2015 09:16
URI: http://eprints.goums.ac.ir/id/eprint/2156

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