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Role of endogenous oxytocin in cardiac ischemic preconditioning

Alizadeh, A.M. and Faghihi, M. and Sadeghipour, H.R. and Mohammadghasemi, F. and Khori, V. (2011) Role of endogenous oxytocin in cardiac ischemic preconditioning. Regulatory Peptides, 167 (1). pp. 86-90. ISSN 01670115 (ISSN)

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Abstract

Background: The aim of the present study is to assess the role of endogenous oxytocin (OT) in cardioprotective effects of ischemic preconditioning (IPC) in anesthetized rat. Materials and methods: Animals were divided into five groups: 1) ischemia-reperfusion (IR); (n= 6), hearts were subjected to 25 min regional ischemia and 60 min reperfusion, 2) OT; (n= 6), oxytocin was administered (0.03. μg/kg i.p) 10 min prior to ischemia, 3) IPC; (n= 7), IPC was induced via a 5 min regional ischemia followed by 5 min of reperfusion before IR, 4) IPC. +. ATO (Atosiban); (n= 6), atosiban (1.5. μg/kg i.p) was used as OT receptor selective antagonist in the beginning of IPC and 5) IR. +. ATO; (n= 6), atosiban was injected 10 min prior to ischemia-reperfusion. Results: In our experiment, Infarct size was decreased significantly in OT and IPC groups compared to IR (23 ± 1.5% and 19 ± 0.6% vs 45 ± 2.9% in IR group, P < 0.05). Administration of atosiban in IPC. +. ATO group increased infarct size to 39 ± 0.9% in comparison with OT and IPC groups (P<0.05). The use of OT and IPC prior to ischemia significantly declined ventricular arrhythmias severity in compared to IR group (1.2±0.4 and 1 ±0.5 respectively, vs 4±0.4 in IR group, P<0.05). Blockade of OT receptor by atosiban abolished the cardiopreconditioning effects of IPC. Conclusion: This study shows that, in part, the cardioprotective effects of IPC can be induced by endogenous OT. © 2010 Elsevier B.V.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Regul. Pept. [Field not mapped to EPrints] C2 - 21130120 [Field not mapped to EPrints] AD - Department of Physiology, School of Medicine, Tehran University of Medical Science, Tehran, Iran [Field not mapped to EPrints] AD - Cancer Research Center, Tehran University of Medical Science, Tehran, Iran [Field not mapped to EPrints] AD - Cellular and Molecular Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran [Field not mapped to EPrints] AD - Golestan Cardiovascular Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Atosiban, Ischemic preconditioning, Oxytocin, atosiban, creatine kinase MB, lactate dehydrogenase, oxytocin, oxytocin receptor, adverse outcome, animal experiment, animal model, animal tissue, article, cardiovascular effect, cardiovascular risk, controlled study, disease severity, heart hemodynamics, heart infarction, heart infarction prevention, heart infarction size, heart muscle ischemia, heart muscle reperfusion, heart protection, heart ventricle arrhythmia, hormone action, ischemic preconditioning, male, nonhuman, priority journal, rat, reperfusion injury, Animals, Arrhythmias, Cardiac, Cardiotonic Agents, Heart, Hemodynamics, Hormone Antagonists, Ischemic Preconditioning, Myocardial, Male, Myocardial Infarction, Myocardial Reperfusion Injury, Oxidative Stress, Oxytocin, Rats, Rats, Wistar, Severity of Illness Index, Vasotocin, Animalia, Rattus
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 03:59
Last Modified: 20 Jun 2015 08:00
URI: http://eprints.goums.ac.ir/id/eprint/2147

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