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Increase in formalin-induced tonic pain by 5alpha-reductase and aromatase inhibition in female rats

Moradi-Azani, M. and Ahmadiani, A. and Amini, H. (2011) Increase in formalin-induced tonic pain by 5alpha-reductase and aromatase inhibition in female rats. Pharmacology Biochemistry and Behavior, 98 (1). pp. 62-66. ISSN 00913057 (ISSN)

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Abstract

Little is known about the role of steroidogenic enzymes in pain modulation. This study examined the effects of 5α-reductase and aromatase inhibition on formalin-induced tonic pain (FITP) in adult female rats. The animals received subcutaneous injection (5 mg/kg) of finasteride (an inhibitor of 5α-reductase) and letrozole (an inhibitor of aromatase), either separately or in combination, 15 min before formalin injection at a low (0.25%) and high (2.5%) concentration. Pretreatment with inhibitors increased FITP evoked by injection of 0.25% formalin, but they were not effective on 2.5% formalin pain. The enhancing effects of finasteride and letrozole on FITP induced by 2.5% formalin was demonstrated by inhibitory actions of these drugs on morphine (7 and 10 mg/kg, intraperitoneal) induced antinociception. The nervous system could be considered as the main target of the enzymes inhibition, since the pronociceptive effect was also observed after administration of inhibitors to ovariectomized rats. Altogether, these findings suggest that the biological activity of the enzymes 5α-reductase and aromatase modulates FITP and may help to develop effective therapeutic strategies to counteract pain. © 2010 Elsevier Inc.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Pharmacol. Biochem. Behav. [Field not mapped to EPrints] C2 - 21184774 [Field not mapped to EPrints] AD - Department of Pharmacology, Neuroscience Research Center, Golestan University of Medical Sciences, P.O. Box: 49175-553, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Pharmacology, Neuroscience Research Center, Shaheed Beheshti University (M.C.), Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: 5alpha-reductase, Aromatase, Formalin test, Morphine, Ovariectomy, aromatase, finasteride, formaldehyde, letrozole, morphine sulfate, steroid 5alpha reductase, animal experiment, antinociception, article, controlled study, dose response, drug inhibition, enzyme activity, enzyme inhibition, female, nociception, nonhuman, ovariectomy, priority journal, rat, 5-alpha Reductase Inhibitors, Analgesics, Opioid, Animals, Aromatase Inhibitors, Drug Synergism, Female, Finasteride, Formaldehyde, Morphine, Nitriles, Ovariectomy, Pain, Pain Measurement, Rats, Rats, Wistar, Triazoles, Animalia, Rattus
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 08:22
Last Modified: 17 Oct 2016 09:39
URI: http://eprints.goums.ac.ir/id/eprint/2146

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