Golestan University of Medical Sciences Repository

Prognostic significance of MMP2 and MMP9 functional promoter single nucleotide polymorphisms in head and neck squamous cell carcinoma

Hajihoseini, S. and Bahmani, M.K. and Khosravi, A. and Ghezelsofla, E. and Ghaderi, A. (2011) Prognostic significance of MMP2 and MMP9 functional promoter single nucleotide polymorphisms in head and neck squamous cell carcinoma. Iranian Journal of Basic Medical Sciences, 14 (2). pp. 137-144. ISSN 20083866 (ISSN)

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Abstract

Objective(s): Matrix metalloproteinases comprise a family of enzyme that is able to degrade components of extra cellular matrix. There are single nucleotide polymorphisms in the promoter regions of several genes with ability to influence cancer susceptibility. The aim of this study was to analyses association between MMP2 and MMP9 promoter polymorphisms and head and neck squamous cell carcinoma occurrence and progression. Materials and Methods: A case- control study was performed including 80 head and neck squamous cell carcinoma patients and healthy controls for MMP2 and 86 head and neck squamous cell carcinoma patients and 72 healthy controls for MMP9. Blood samples were genotyped for MMP2 and MMP9 using polymerization chain reaction- restriction fragment length polymorphism method (PCR-RFLP). Statistical analysis was performed using SPSS 12.0 software. Results: Our results showed that distribution of MMP2 genotype between controls and patients was significantly different (�2= 10.3, P= 0.005). Comparison between CC genotype in HNSCC patients and controls showed that C allele modified the risk of HNSCC progression (OR= 2.6, 95% CI, 1.0046-6.729). The MMP9 genotype distribution among HNSCC patients was significantly different (�2= 14.56, P= 0.0007). The frequency of TT genotype in HNSCC patients was different from healthy controls and was more common genotype in HNSCC cases (OR= 2.18, 95% CI, 0.7052-6.7854). Conclusion: Our results suggested an association of the MMP2 and MMP9 SNP with the development of HNSCC. Also, our results showed that MMP, MMP9 genotypes and smoking were related to HNSCC progression.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Iran. J. Basic Med. Sci. [Field not mapped to EPrints] AD - HIV and Hepatitis Research Center, Faculty of Laboratorial Sciences, Gerash, Fars, Iran [Field not mapped to EPrints] AD - Golestan University of Medical Sciences, Gorgan, Golestan, Iran [Field not mapped to EPrints] AD - Cancer Research Institute, Shiraz University of Medical Sciences, Shiraz, Fars, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Extra cellular matrix, Head and neck squamous cell carcinoma, Matrix metalloproteinase, gelatinase A, gelatinase B, adolescent, adult, aged, allele, article, blood sampling, cancer growth, case control study, controlled study, female, genetic association, genetic polymorphism, genotype, head and neck carcinoma, human, major clinical study, male, polymerase chain reaction, prognosis, restriction fragment length polymorphism, single nucleotide polymorphism, squamous cell carcinoma
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 05:45
Last Modified: 15 Jun 2015 06:07
URI: http://eprints.goums.ac.ir/id/eprint/2145

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