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Myocardial perfusion imaging using a technetium-99m Sestamibi in asymptomatic and low risk for coronary artery disease patients with diagnosed systemic lupus erythematosus

Baharfard, N. and Fotoohi, F. and Samangooie, S. and Eghtesadi-Araghi, P. and Javadi, H. and Semnani, S. and Amini, A. and Assadi, M. (2011) Myocardial perfusion imaging using a technetium-99m Sestamibi in asymptomatic and low risk for coronary artery disease patients with diagnosed systemic lupus erythematosus. Perfusion, 26 (2). pp. 151-157. ISSN 02676591 (ISSN)

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Abstract

Introduction: The aim of the present study was to evaluate technetium-99m sestamibi single photon emission tomography (SPECT) myocardial perfusion imaging (MPI) and its association with some clinical and laboratory parameters in an asymptomatic systemic lupus erythematosus (SLE) population. Materials and Methods : Twenty-one subjects with SLE and no suspected or documented coronary artery disease (CAD) accomplished myocardial perfusion imaging. Some SLE and CAD parameters were also evaluated in association with myocardial SPECT. Results: Twenty-one women with a diagnosis of SLE (mean age 36.9 ± 12.8) entered the study. All patients were in the low-risk category for CAD pretest; however, abnormal myocardial perfusion results were found in eight (38%) patients. Amongst the traditional CAD risk factors, there was a significant association between the presence of dyslipidemia and myocardial perfusion abnormalities (P= 0.047). However, we found no significant association between other traditional and SLE-specific risk factors. Conclusion: This study's significant finding was that asymptomatic CAD is common in SLE patients, even in those thought to be low risk for CAD and in the absence of cardiac symptoms. © The Author(s) 2010.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Perfusion [Field not mapped to EPrints] C2 - 21078771 [Field not mapped to EPrints] AD - Department of Nuclear Medicine, Taleghani Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Department of Rheumatology, Taleghani Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Parsteb Pajouheshyar Medical Sciences Research Institute, Tehran, Iran [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences (GUOMS), Gorgan, Iran [Field not mapped to EPrints] AD - Bushehr Research Center for Nuclear Medicine, Persian Gulf Biomedical Sciences Institute, Bushehr University of Medical Sciences, Boostan 19 Alley, Imam Khomeini Street, Bushehr, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: coronary artery disease, myocardial perfusion imaging., risk factors, SPECT, systemic lupus erythematosus, C reactive protein, cardiolipin antibody, complement, corticosteroid, dipyridamole, double stranded DNA antibody, methoxy isobutyl isonitrile technetium tc 99m, adult, antibody blood level, article, blood cell count, body mass, clinical article, coronary artery disease, coronary risk, corticosteroid therapy, diabetes mellitus, disease duration, disease severity, dyslipidemia, family history, female, heart muscle perfusion, human, hypertension, menopause, myocardial disease, myocardial perfusion imaging, pharmacologic stress testing, priority journal, protein blood level, proteinuria, single photon emission computer tomography, smoking, systemic lupus erythematosus, Adult, Coronary Artery Disease, Female, Humans, Lupus Erythematosus, Systemic, Middle Aged, Myocardial Perfusion Imaging, Risk Factors, Technetium Tc 99m Sestamibi, Tomography, Emission-Computed, Single-Photon, Young Adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 08:09
Last Modified: 13 May 2015 10:11
URI: http://eprints.goums.ac.ir/id/eprint/2144

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