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Chronic stress prior to hippocampal stroke enhances post-stroke spatial deficits in the ziggurat task

Faraji, J. and Ejaredar, M. and Metz, G.A. and Sutherland, R.J. (2011) Chronic stress prior to hippocampal stroke enhances post-stroke spatial deficits in the ziggurat task. Neurobiology of Learning and Memory, 95 (3). pp. 335-345. ISSN 10747427 (ISSN)

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Abstract

Stress is one of the most important variables to determine recovery following stroke. We have previously reported that post-stroke exposure to either stress or corticosterone (CORT) alleviates hippocampal ischemic outcome. The present experiment expands previous findings by investigating the influence of exposure to stress prior to ischemic event. Rats received either daily restraint stress (1. h/day; 16 consecutive days) or CORT (0.5. mg/kg; 16 consecutive days) prior to focal ischemic stroke in the hippocampus induced by bilateral injection of endothelin-1 (ET-1). All experimental groups were then tested in the ziggurat task, a new task for spatial cognition. The stress. +. stroke group showed significant deficits in both hippocampal structure and function. No deleterious effect of pre-stroke exposure to CORT was found in the CORT. +. stroke group. Our results indicate that a history of chronic stress sensitizes hippocampal cells to the damaging consequences of focal ischemia. The opposing effects of CORT-related experiences in this study not only reflect the diversity of glucocorticoid actions in the stress response, but also provide evidence that elevated CORT in the absence of emotional disturbance is not sufficient to produce hippocampal deficit. © 2011 Elsevier Inc.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Neurobiol. Learn. Mem. [Field not mapped to EPrints] C2 - 21256969 [Field not mapped to EPrints] AD - Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada [Field not mapped to EPrints] AD - Neuroscience Research Centre, Golestan University of Medical Sciences, P.O. Box 49165-568, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Endothelin-1, Hippocampal stroke, Restraint stress, Spatial performance, Ziggurat task, corticosterone, endothelin 1, animal experiment, animal model, animal tissue, article, brain function, cerebrovascular accident, chronic stress, cognitive defect, controlled study, depth perception, experimental test, hippocampus, male, mental performance, mental task, neuropathology, nonhuman, rat, ziggurat task, Animals, Chronic Disease, Corticosterone, Disease Models, Animal, Endothelin-1, Glucocorticoids, Hippocampus, Male, Maze Learning, Problem Solving, Rats, Rats, Long-Evans, Spatial Behavior, Stress, Physiological, Stroke, Time Factors
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 05:46
Last Modified: 14 May 2015 02:52
URI: http://eprints.goums.ac.ir/id/eprint/2142

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