Golestan University of Medical Sciences Repository

The correlation between endothelin-1 antibody plasma concentrations in patients with scleroderma and different manifestations of the disease

Aghaei, M. and Gharibdost, F. and Zayeni, H. and Akhlaghi, M. and Sedighi, S. and Rostamian, A.R. and Aghdami, N. and Shojaa, M. (2011) The correlation between endothelin-1 antibody plasma concentrations in patients with scleroderma and different manifestations of the disease. Tehran University Medical Journal, 68 (12). pp. 699-704. ISSN 16831764 (ISSN)

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Abstract

Background: Systemic scleroderma (SSc) is a generalized connective tissue disorder of unknown origin which most notably is characterized by skin thickening and organ damage. Endothelin-1 (ET-1) antibody plays a role in skin fibrosis. The aim of this study was to determine the prevalence and correlation of different manifestations of SSc with ET-1 plasma levels. Methods: This cross-sectional analytical study was conducted on 95 patients (91 women and four men) with scleroderma in 2006. The patients had been referred to the Rheumatology Clinic of Shariati Hospital in Tehran, Iran. The demographic data and signs and symptoms were entered in a questionnaire and endothelin-1 concentrations were measured. Results: The mean age of the patients was 38+12.29 years. Diffuse cutaneous SSc (dcSSc) was diagnosed in 52 and limited cutaneous SSc (lcSSc) in 43 patients. Raynaud's phenomenon (91%) was the most common manifestation in the patients. The relationship between the resorption of terminal phalanges due to fibrosis with the plasma concentration of Endothelin-1 was statistically significant (p=0.001). Pitting ulcers had significant relationships with endothelin-1 concentrations too (p<0.05). No other significant relationships were found between the other manifestation of the disease and Endothelin-1 concentration. Conclusion: In this study, Reynaud's phenomenon was the most frequent sign in patients with scleroderma. Thus, it could serve as a tool for the diagnosis of scleroderma. As there were no significant relationships between the other manifestations of scleroderma with endothelin-1, a cohort study with a larger sample size is suggested.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - Persian [Field not mapped to EPrints] J2 - Tehran Uni. Med. J. [Field not mapped to EPrints] AD - Department of Rheumatolog, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Department of Rheumatology, Gilan University of Medical Sciences, Gilan, Iran [Field not mapped to EPrints] AD - Department of Rheumatology, Imam Hospital, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Osteoporosis Research Center, Endocrinology and Metabolism Institute, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Clinical, Endotheline, Manifestation, Raynaud's phenomenon, Scleroderma, endothelin 1, endothelin 1 antibody, protein antibody, unclassified drug, article, clinical feature, cohort analysis, cross-sectional study, demography, diffuse scleroderma, female, fibrosis, human, Iran, localized scleroderma, major clinical study, male, osteolysis, patient referral, phalanx, prevalence, protein blood level, questionnaire, Raynaud phenomenon, sample size, scleroderma, skin ulcer, symptom, university hospital
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 04:59
Last Modified: 23 May 2015 06:32
URI: http://eprints.goums.ac.ir/id/eprint/2141

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