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Preventive effect of vitamin B6 on developmental toxicity of carbamazepine in mice

Afshar, M. and Moallem, S.A. and Baharara, J. and Takjo, T. and Golalipour, M.J. (2011) Preventive effect of vitamin B6 on developmental toxicity of carbamazepine in mice. Iranian Journal of Basic Medical Sciences, 14 (2). pp. 99-106. ISSN 20083866 (ISSN)

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Objective(s): Carbamazepine (CBZ) is an antiepileptic drug that is used widely for the treatment of epileptic seizures. Neural tube defects (NTDs), growth retardation, and nail hypoplasia are the most common features of teratogenic effects of this drug. The purpose of this study was to examine the effect of vitamin B6 on the developmental toxicity of CBZ on mice. Materials and Methods: Sixty BALB/c pregnant mice were divided into four experimental and two control groups. Two experimental groups received daily intraperitoneal injection (IP) of 30 mg/kg (I) or 60 mg/kg (II) of CBZ on gestational days (GD) 6 to 15. Two other experimental groups received daily IP injection of 30 mg/kg (III) or 60 mg/kg (IV) of CBZ with 10 mg/kg/day vitamin B6 by gavage 10 days prior to gestation and on GD 6 to 15. Two control groups received normal saline or Tween 20. Dams underwent Cesarean section on GD 18 and embryos were harvested. External/macroscopic observation of fetuses was done by stereomicroscope and external examination for malformations was recorded. Data analyzed by ANOVA and X 2 test using SPSS software. Results: The mean weight and crown-rump of the fetuses in both CBZ-treated experimental groups were significantly reduced compared with those of the control groups. Various malformations were detected such as brachygnathia, eye malformations, NTDs, vertebral deformity, brachydactyly and growth retardation. Vitamin B6 treatment significantly reduced various CBZ-induced malformations. Conclusion: This study showed that vitamin B6 has a preventive effect on the developmental toxicity of CBZ in mice that can be pursued further for clinical research.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Iran. J. Basic Med. Sci. [Field not mapped to EPrints] AD - Department of Anatomy, Birjand University of Medical Sciences, Birjand, Iran [Field not mapped to EPrints] AD - Pharmaceutical Sciences Research Center, Medical Toxicology Research Center, Department of Pharmacodynamics and Toxicology, Mashhad University of Medical Sciences, Mashhad, Iran [Field not mapped to EPrints] AD - Department of Biology, Azad Islamic University of Mashhad, Mashhad, Iran [Field not mapped to EPrints] AD - Gorgan Congenital Malformations Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Carbamazepine, Congenital abnormalities, Mice, Pyridoxine, Teratology, carbamazepine, pyridoxine, analysis of variance, animal experiment, animal model, article, Bagg albino mouse, brachydactyly, brachygnathia, cesarean section, clinical research, controlled study, developmental disorder, drug effect, embryo, experimental study, eye malformation, female, fetus, gestational age, growth retardation, mouse, nonhuman, pregnancy, stereomicroscopy, vertebra malformation, Mus
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 05:44
Last Modified: 13 May 2015 09:20
URI: http://eprints.goums.ac.ir/id/eprint/2140

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