Golestan University of Medical Sciences Repository

Stress after hippocampal stroke enhances spatial performance in rats

Faraji, J. and Metz, G.A. and Sutherland, R.J. (2011) Stress after hippocampal stroke enhances spatial performance in rats. Physiology and Behavior, 102 (3-4). pp. 389-399. ISSN 00319384 (ISSN)

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Abstract

The nature of stress-related cognitive changes is still a matter of debate. Stress is often considered to be deleterious to cognitive function, despite many instances in which beneficial effects are evident in neural structure and cognition. Moreover, in some neuropathological conditions such as focal ischemia, stress exaggerates loss of cognitive function. The present experiments set out to investigate the effects of repeated restraint stress on spatial cognition in rats, and on recovery from a focal stroke induced by injection of endothelin-1 (ET-1) into the hippocampus (HPC). We did not observe a deleterious effect of stress on performance in the Morris water task (MWT). The HPC focal stroke induced by ET-1 produced lasting spatial learning impairments. Importantly, rats in the HPC stroke. +. stress group exhibited superior performance in the MWT compared with the HPC stroke-only group. No between-group structural difference was observed related to stress. These findings confirm that corticosterone-related experiences may be key factors influencing cognitive performance after HPC focal ischemic stroke. © 2010 Elsevier Inc.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Physiol. Behav. [Field not mapped to EPrints] C2 - 21130791 [Field not mapped to EPrints] AD - Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada [Field not mapped to EPrints] AD - Neuroscience Research Centre, Golestan University of Medical Sciences, P.O. Box 49165-568, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Endotheline-1, Hippocampal stroke, Morris water task, Spatial performance, Stress, corticosterone, endothelin 1, animal experiment, animal model, article, cognition, controlled study, experimental test, hippocampus, immobilization stress, learning disorder, male, morris water task, nonhuman, performance, priority journal, rat, spatial performance, stress, stroke, task performance, Analysis of Variance, Animals, Endothelin-1, Hippocampus, Male, Maze Learning, Rats, Rats, Long-Evans, Restraint, Physical, Spatial Behavior, Stress, Physiological, Stress, Psychological, Stroke
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 04:40
Last Modified: 14 May 2015 02:56
URI: http://eprints.goums.ac.ir/id/eprint/2139

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