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Effects of vitamin e and zinc supplementation on antioxidants in beta thalassemia major patients

Rashidi, M. and Aboomardani, M. and Rafraf, M. and Arefhosseini, S.-R. and Keshtkar, A. and Joshaghani, H. (2011) Effects of vitamin e and zinc supplementation on antioxidants in beta thalassemia major patients. Iranian Journal of Pediatrics, 21 (1). pp. 8-14. ISSN 10184406 (ISSN)

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Abstract

Objective: In beta thalassemic patients, tissue damage occurs due to oxidative stress and it happens because of the accumulation of iron in the body. This study was conducted to determine the effect of zinc and vitamin E supplementation on antioxidant status in beta-thalassemic major patients. Methods: This double blind randomized clinical trial was carried out on 120 beta thalassemic patients older than 18 years. Patients were randomly categorized in four groups. Zinc (50mg/day) and vitamin E (400mg/day) supplements were administered for former and latter group, respectively. In the third group both supplements were administered in similar doses. The fourth (control) group received no supplement. The effect of supplementations on serum zinc and vitamin E, superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC) and body mass index (BMI) were measured at the beginning and the end of the study. Findings: Serum zinc levels in group 1 and 3 were significantly increased (P<0.007 and P<0.005, respectively). Serum vitamin E levels in group 2 and 3 were also increased significantly (P<0.001). Mean GPX activity in group1, 2 and 3 decreased significantly (P<0.015, P<0.032 and P<0.029, respectively). Mean SOD activity and TAC did not show significant change after supplementation. BMI had significant increase in all treated groups (P<0.001). Conclusion: Our results suggest that beta thalassemic patients have enhanced oxidative stress and administration of selective antioxidants may preclude oxidative damage. © 2011 by Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, All rights reserved.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Iran. J. Pediatr. [Field not mapped to EPrints] AD - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran [Field not mapped to EPrints] AD - Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran [Field not mapped to EPrints] AD - Nutritional Research Center, Tabriz University of Medical Sciences, Tabriz, Iran [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Antioxidants, Body mass index, Glutathione peroxidase, Superoxide dismutase, Vitamin e, Zinc, alpha tocopherol, glutathione peroxidase, superoxide dismutase, zinc, adult, alpha tocopherol deficiency, article, body mass, controlled study, double blind procedure, enzyme activity, enzyme blood level, female, human, major clinical study, male, oxidative stress, randomized controlled trial, thalassemia major, treatment outcome, vitamin blood level, vitamin supplementation, zinc blood level, zinc deficiency
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 06:49
Last Modified: 16 May 2015 11:15
URI: http://eprints.goums.ac.ir/id/eprint/2132

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