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Appendicectomy and multiple sclerosis risk

Roshanisefat, H. and Bahmanyar, S. and Hillert, J. and Olsson, T. and Montgomery, S.M. (2011) Appendicectomy and multiple sclerosis risk. European Journal of Neurology, 18 (4). pp. 667-669. ISSN 13515101 (ISSN)

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Abstract

Background: Appendicectomy for acute appendicitis, but not for other causes, is inversely associated with immune-mediated diseases such as ulcerative colitis, suggesting appendicitis is a marker of immune characteristics influencing immune-mediated disease risk. This study investigated the association of appendectomy and its underlying diagnosis with multiple sclerosis (MS). Methods: Swedish general population registers and the Swedish MS register provided information on 20542 cases with MS diagnosed between 1964-2006 and 204157 controls matched for age, sex, period and region. Appendicectomy prior to MS diagnosis was identified in 673 cases and 6518 controls. Conditional logistic regression, with adjustment for socio-economic index, assessed the association of diagnosis underlying appendicitis with MS risk. Results: A perforated appendix, the best indicator of acute appendicitis in this material, was inversely associated with MS, although not statistically significantly, with an odds ratio (and 95% confidence interval of 0.86 (0.70-1.04). The odds ratios are 1.04 (0.94-1.16) for appendicitis without perforation and 1.14 (0.98-1.33) for appendectomy without appendicitis. Conclusion: Although inconclusive in terms of assessing the hypothesis, these results may help to explain why earlier studies of appendicitis and MS risk have been inconsistent, as there may be variation in association by diagnosis underlying appendicectomy. © 2010 The Author(s). European Journal of Neurology © 2010 EFNS.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Eur. J. Neurol. [Field not mapped to EPrints] C2 - 20629715 [Field not mapped to EPrints] AD - Department of Neurology, Karolinska University Hospital, Huddinge, Sweden [Field not mapped to EPrints] AD - Clinical Epidemiology Unit, Karolinska Institute, Stockholm, Sweden [Field not mapped to EPrints] AD - Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Division of Neurology, Department of Clinical Neuroscience, Karolinska University Hospital-Huddinge, Karolinska Institutet, Sweden [Field not mapped to EPrints] AD - Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden [Field not mapped to EPrints] AD - �rebro University Hospital, �rebro, Sweden [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Appendicitis, Appendix, Immune-mediated, Multiple sclerosis, Surgery, acute appendicitis, adult, appendectomy, appendix perforation, article, case control study, controlled study, disease association, disease registry, female, human, major clinical study, male, multiple sclerosis, priority journal, sex difference, socioeconomics, Sweden, Adult, Appendectomy, Appendicitis, Case-Control Studies, Female, Humans, Male, Multiple Sclerosis, Sweden, Young Adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 04:06
Last Modified: 16 May 2015 15:06
URI: http://eprints.goums.ac.ir/id/eprint/2129

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